ArticleInternational orthopaedics2021
High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture.
Article in International orthopaedics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of multidimensional biomarkers of immune, nutritional, inflammatory, and metabolic status with postoperative outcomes in older hip fracture patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Epidemiology, patient outcome and complications after non-operative management of hip fracture: a systematic review.Anaesthesia · 2025Pooled it
- Development and internal validation of prediction model for 90-day mortality in older patients with hip fracture using admission blood parameters.BMC geriatrics · 2026Article
- Relationship between inflammatory indicators and bone mineral density in preschool children.Pediatric research · 2026Article
- Predictive value of shock indices in 30-day mortality for elderly hip fracture patients: a retrospective cohort study.Acta orthopaedica et traumatologica turcica · 2026Article
- Preoperative RDW-Based composite score for predicting mortality after hip fracture surgery.BMC musculoskeletal disorders · 2026Article
- Prognostic value of three inflammatory markers for mortality after hip fracture in the geriatric population.Scientific reports · 2025Article
- Postoperative Hypoalbuminemia as a Predictor of Early Mortality After Cementless Hemiarthroplasty for Hip Fractures.Medicina (Kaunas, Lithuania) · 2025Article
- Independent risk factors and survival prediction in hip refractures patients: insights from a 10-year cohort.Journal of bone and mineral metabolism · 2025Article
- Correlation of Preoperative Inflammation/Immunity Markers With Postoperative Urinary Tract Infections in Elderly Hip Fracture Patients.Orthopaedic surgery · 2025Article
- Relationship between mortality and HALP score in femoral neck fractures treated with hemiarthroplasty.Joint diseases and related surgery · 2025Article
- Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations.Journal of inflammation research · 2025Article
- Blood indicators for short-term mortality risk in older patients with hip fracture: association and predictive value.Frontiers in medicine · 2025Article
- The predictive role of platelet-to-lymphocyte ratio and systemic immune-inflammation index in young and middle-aged patients with tibial plateau fractures.Frontiers in surgery · 2025Article
- The hemoglobin, albumin, lymphocyte, and platelet score as a useful predictor for mortality in older patients with hip fracture.Frontiers in medicine · 2025Article
- Multivariate analysis of blood parameters for predicting mortality in patients with hip fractures.Experimental and therapeutic medicine · 2024Article
- Prediction of Osteoporotic Hip Fracture Outcome: Comparative Accuracy of 27 Immune-Inflammatory-Metabolic Markers and Related Conceptual Issues.Journal of clinical medicine · 2024Article
- Association between inflammation-based prognostic markers and mortality after hip replacement.Scientific reports · 2024Article
- Observational
- Combined Systemic Immune-inflammatory Index (SII) and Geriatric Nutritional Risk Index (GNRI) predict survival in elderly patients with hip fractures: a retrospective study.Journal of orthopaedic surgery and research · 2024Article
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6 authors.
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Abstract
purposeThe platelet-to-lymphocyte ratio (PLR) has been extensively studied in various diseases. However, the relationship between PLR and hip fracture remains unknown. The aim of this study was to evaluate whether PLR would be an independent prognostic factor in elderly hip fracture patients.
methodsBetween January 2014 and December 2018, a retrospective cohort study was conducted in a orthopaedic centre, China. A total of 460 hip fracture patients were included. PLR was calculated as the ratio of platelet to lymphocyte counts and divided into high PLR group (≥ 189) and low PLR group (< 189) by using the receiver operating characteristic (ROC) curve. The relationship between PLR and one year all-cause mortality rate was assessed by univariate and multivariate Cox proportional hazard models. Further subgroup analysis stratified by different clinical and biological characteristics was performed to make the results more accurate.
resultsAfter a median follow-up of 32.0 months (range, 12.0-75.4), 92 patients (mortality rate: 20.0%) died within one year. PLR was significantly higher in dead patients compared with alive patients (p < 0.05), and high PLR group also had a high mortality rate (32.21% vs. 14.15%, p < 0.001). After multivariate adjustment, high PLR remained an independent predictor for one year all-cause mortality (adjusted hazard ratio (HR) 1.56, 95% confidence interval (CI) 1.02-2.41, p = 0.041). Moreover, advanced age (HR 1.05, 95% CI 1.01-1.08), male (HR 1.62, 95% CI 1.06-2.45), CCI ≥ 2 (HR 2.83, 95% CI 1.64-4.89), conservative treatment (HR 5.94, 95% CI 3.71-9.73), low haemoglobin level (HR 1.02, 95% CI 1.01-1.04), and low albumin level (HR 1.07, 95% CI 1.02-1.13) were independent risk factors for survival. Furthermore, subgroup analysis results were consistent with the main findings in most stratified groups.
conclusionThis study highlights that high PLR (≥ 189) is associated with increased one year all-cause mortality in elderly hip fracture patients. As PLR is a simple indicator that can be calculated from the blood routine test, it can be easily performed in usual clinical practice.
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