ArticleNature immunology2020
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 92 citations in OpenAlex.
- Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate.Nature immunology · 2026Article
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells.EMBO reports · 2026Article
- Engineered dCas12f1-SAM enables robust transcriptional activation and gain-of-function screening in primary human cells.Nature communications · 2026Article
- Rewiring miR-22/SNAI1 via CRISPR-based edge editing destabilizes the epithelial phenotype.NPJ systems biology and applications · 2026Article
- The Roles of the PRDM Family in the Neuro-Motor System.Biomolecules · 2026Review
- SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells.bioRxiv : the preprint server for biology · 2026Article
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
- Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets.Nature communications · 2025Article
- Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M.Inflammation · 2025Article
- BLIMP-1 and CEACAM1 cooperatively regulate human Treg homeostasis and function to control xenogeneic GVHD.JCI insight · 2025Article
- Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematoma.Journal of neuroinflammation · 2025Article
- Systematic characterization of the ovarian landscape across mouse menopause models.bioRxiv : the preprint server for biology · 2025Article
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- Reducing batch effects in single cell chromatin accessibility measurements by pooled transposition with MULTI-ATAC.bioRxiv : the preprint server for biology · 2025Article
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- Article
- Reduced circulating regulatory T cells in primary Sjögren's syndrome: the contribution of enhanced apoptosis and impaired survival.Frontiers in immunology · 2025Article
- Unraveling the future of genomics: CRISPR, single-cell omics, and the applications in cancer and immunology.Frontiers in genome editing · 2025Review
- Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice.Frontiers in immunology · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 2 countries.
Kathrin Schumann *Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany. kathrin.schumann@tum.de.ORCID http://orcid.org/0000-0002-0993-3910
Siddharth S Raju *Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3916-0293
Michael LauberInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Saskia KolbInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Eric ShifrutDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6827-0128
Jessica T CortezDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Nikolaos SkartsisDepartment of Medicine, University of California, San Francisco, CA, USA.
Vinh Q NguyenDepartment of Surgery, University of California, San Francisco, CA, USA.
Jonathan M WooDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Theodore L RothDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3970-9573
Ruby YuDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Michelle L T NguyenDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
Dimitre R SimeonovDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.
David N NguyenDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6808-2717
Sasha TargDepartment of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.
Rachel E GateDepartment of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.
Qizhi TangDiabetes Center, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7313-3574
Jeffrey A BluestoneDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8793-7848
Matthew H SpitzerDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5291-3819
Chun Jimmie YeDepartment of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6560-3783
Alexander MarsonDepartment of Microbiology and Immunology, University of California, San Francisco, CA, USA. alexander.marson@ucsf.edu.ORCID http://orcid.org/0000-0002-2734-5776
University of California, San Francisco · USInstitute for Advanced Study · DEBroad Institute · USGladstone Institutes · USInstitute of Medical Microbiology and Hygiene · DE
Funding
X-ray Screening and Rapid Structure DeterminationP50GM082250 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANKEL, ALAN D · 2007 to 2018
$48.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MRESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2MFunctional Interrogation of Non-Coding Type 1 Diabetes Risk Variants in Human Immune Cells and Beta CellsDP3DK111914 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSON, ALEXANDER · 2016 to 2016
$3.7MQuantitatively modeling immune responses to cancerDP5OD023056 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPITZER, MATTHEW · 2016 to 2020
$1.9MNIAID NIH HHS L40 AI140341NIAID NIH HHS T32 AI007334NIAMS NIH HHS P30 AR070155NIDDK NIH HHS DP3 DK111914NIDDK NIH HHS P30 DK063720NIGMS NIH HHS P50 GM082250NIGMS NIH HHS T32 GM007618NIH HHS DP5 OD023056
Abstract
Human regulatory T (T
Indexed as
Clustered Regularly Interspaced Short Palindromic RepeatsGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksTranscriptomeBiomarkersCRISPR-Cas SystemsDisease SusceptibilityGene Knockout TechniquesGene TargetingGraft vs Host DiseaseHigh-Throughput Nucleotide SequencingHumansT-Lymphocytes, RegulatoryBiomarkers
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.