Evidence map›Paper›PMID 32989327›Full record

ArticleNature immunology2020

Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions.

Juliet M Bartleson, Ashley A Viehmann Milam, David L Donermeyer, Stephen Horvath, Yu Xia, Takeshi Egawa, Paul M Allen

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. A Dapl1Science advances · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Presetting CAR-T cells during ex vivo biomanufacturing.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  13. The Biology of Dendritic Cells: In Health and Disease.Advances in experimental medicine and biology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Juliet M BartlesonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Ashley A Viehmann MilamDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
David L DonermeyerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Stephen HorvathDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Yu XiaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Takeshi EgawaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Paul M AllenDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. pallen@wustl.edu.ORCID http://orcid.org/0000-0003-3796-6047
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI David W Piston · 2018 to 2026
$7.6M
The transcription factor c-MYC in lymphocyte expansion and restriction of stemnessR01AI130152 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2017 to 2026
$4.6M
Strength of TCR:self-pMHC interactions in the periphery instructs CD4+ T help cell responsesR01AI139540 · NIAID · WASHINGTON UNIVERSITY · PI MORLEY, SHARON CELESTE · 2019 to 2023
$2.3M
THE ROLE OF TH1 CD4 T CELLS IN CONTROL OF VIRAL INFECTIONR03AI139875 · NIAID · WASHINGTON UNIVERSITY · PI EGAWA, TAKESHI · 2018 to 2019
$156k
Defining and Modulating the Quality of a CD4+ T 'Helper' Cell ResponseF31AI138393 · NIAID · WASHINGTON UNIVERSITY · PI BARTLESON, JULIET MARIE · 2019 to 2020
$62k
NCI NIH HHS P30 CA091842NIAID NIH HHS F31 AI138393NIAID NIH HHS R01 AI130152NIAID NIH HHS R01 AI139540NIAID NIH HHS R03 AI139875NIAMS NIH HHS P30 AR073752
6 · The paper itself

Abstract

T follicular helper (T

Indexed as

Signal TransductionAnimalsAntigensCD4-Positive T-LymphocytesCell DifferentiationH-2 AntigensImmunizationImmunophenotypingLymphocyte ActivationMiceMice, KnockoutMice, TransgenicPeptidesReceptors, Antigen, T-CellT Follicular Helper CellsAntigensH-2 AntigensPeptidesReceptors, Antigen, T-Cell

Identifiers

PMID32989327
PMCPMC7578106
OpenAlexW3091149611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.