ArticleNature genetics2020
Analysis of wild tomato introgression lines elucidates the genetic basis of transcriptome and metabolome variation underlying fruit traits and pathogen response.
Article in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
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Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it, 180 citations in OpenAlex.
- Multi-omics revolution to promote plant breeding efficiency.Frontiers in plant science · 2022Pooled it
- SlTCP16 confers disease resistance in tomato via a dual regulatory mechanism involving transcriptional activation and protein interaction with Sl4CL3.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Graph-based pangenomics reveals the genetic basis of agronomic traits in tomato fruits.Horticulture research · 2026Article
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- Genetic basis of alkaloid divergence in the Solanaceae.Plant molecular biology · 2026Article
- Genome-wide association studies in horticultural crops: decoding genetic diversity for precision breeding.Horticulture research · 2026Article
- Engineering carotenoid and steroidal glycoalkaloid depleted tomato fruit for heterologous production of high value terpenes.bioRxiv : the preprint server for biology · 2026Article
- A rare glycoalkaloid biosynthetic pathway from wild potato unlocks genetic routes to Colorado potato beetle resistance.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana.Plant biotechnology journal · 2026Article
- Genetic architecture of the tomato fruit lipidome.PNAS nexus · 2026Article
- panomiX: Investigating mechanisms of trait emergence through multi-omics data integration.Plant phenomics (Washington, D.C.) · 2025Article
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- Tomato and its relatives are breaking the genomics barriers.Journal of experimental botany · 2025Review
- What metabolomics has taught us about tomato fruit ripening and quality.Journal of experimental botany · 2025Review
- Co-option of transcription factors drives evolution of quantitative disease resistance against a necrotrophic pathogen.The Plant cell · 2025Article
- Article
- Biofortification of potato nutrition.Journal of advanced research · 2025Review
- A SlMYB78-regulated bifunctional gene cluster for phenolamide and salicylic acid biosynthesis during tomato domestication, reducing disease resistance.Journal of integrative plant biology · 2025Article
- Fine-mapping of sm6.1, a novel locus conferring resistance to gray leaf spot from Solanum habrochaites accession LA1777.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wild tomato species represent a rich gene pool for numerous desirable traits lost during domestication. Here, we exploited an introgression population representing wild desert-adapted species and a domesticated cultivar to establish the genetic basis of gene expression and chemical variation accompanying the transfer of wild-species-associated fruit traits. Transcriptome and metabolome analysis of 580 lines coupled to pathogen sensitivity assays resulted in the identification of genomic loci associated with levels of hundreds of transcripts and metabolites. These associations occurred in hotspots representing coordinated perturbation of metabolic pathways and ripening-related processes. Here, we identify components of the Solanum alkaloid pathway, as well as genes and metabolites involved in pathogen defense and linking fungal resistance with changes in the fruit ripening regulatory network. Our results outline a framework for understanding metabolism and pathogen resistance during tomato fruit ripening and provide insights into key fruit quality traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.