ArticleNature chemical biology2020
Glucosylation prevents plant defense activation in phloem-feeding insects.
Article in Nature chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Two-component plant defenses are better than one.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An integrative strategy used by the aphid Uroleucon formosanum to counter host sesquiterpene lactone defense: Insights from combined genomic and transcriptomic analysis.Insect science · 2025Article
- Chromosome-level genome assembly of Sambus kanssuensis (Coleoptera: Buprestidae).Scientific data · 2025Article
- Functional Carbohydrate-Active Enzymes Acquired by Horizontal Gene Transfer from Plants in the Whitefly Bemisia tabaci.Genome biology and evolution · 2025Article
- Methyl Jasmonate Enhances the Resistance ofInsects · 2025Article
- Plant Cyanogenic-Derived Metabolites and Herbivore Counter-Defences.Plants (Basel, Switzerland) · 2024Review
- Feeding-induced plant metabolite responses to a phoretic gall mite, its carrier psyllid and both, after detachment.Experimental & applied acarology · 2023Article
- The silkworm (Bombyx mori) gut microbiota is involved in metabolic detoxification by glucosylation of plant toxins.Communications biology · 2023Article
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- Harmonizing biosynthesis with post-ingestive modifications to understand the ecological functions of plant natural products.Natural product reports · 2022Review
- Unique metabolism of different glucosinolates in larvae and adults of a leaf beetle specialised on Brassicaceae.Scientific reports · 2022Article
- The downside of metabolic diversity: Postingestive rearrangements by specialized insects.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanisms of Isothiocyanate Detoxification in Larvae of Two Belowground Herbivores,Frontiers in physiology · 2022Article
- Silencing the gustatory receptor BtGR11 affects the sensing of sucrose in the whiteflyFrontiers in bioengineering and biotechnology · 2022Article
- Activation and detoxification of cassava cyanogenic glucosides by the whitefly Bemisia tabaci.Scientific reports · 2021Article
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- Identification of a Sulfatase that Detoxifies Glucosinolates in the Phloem-Feeding InsectFrontiers in plant science · 2021Article
- Supplementing Blood Diet With Plant Nectar Enhances Egg Fertility inFrontiers in physiology · 2021Article
- Making use of surplus sugar.Nature chemical biology · 2020Article
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic adaptations by which phloem-feeding insects counteract plant defense compounds are poorly known. Two-component plant defenses, such as glucosinolates, consist of a glucosylated protoxin that is activated by a glycoside hydrolase upon plant damage. Phloem-feeding herbivores are not generally believed to be negatively impacted by two-component defenses due to their slender piercing-sucking mouthparts, which minimize plant damage. However, here we document that glucosinolates are indeed activated during feeding by the whitefly Bemisia tabaci. This phloem feeder was also found to detoxify the majority of the glucosinolates it ingests by the stereoselective addition of glucose moieties, which prevents hydrolytic activation of these defense compounds. Glucosylation of glucosinolates in B. tabaci was accomplished via a transglucosidation mechanism, and two glycoside hydrolase family 13 (GH13) enzymes were shown to catalyze these reactions. This detoxification reaction was also found in a range of other phloem-feeding herbivores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.