Evidence map›Paper›PMID 32989260›Full record

ArticleProstate cancer and prostatic diseases2021

Protective effect of pharmacological castration on metabolic perturbations and cardiovascular disease in the hyperglycemic male ApoE

Wilhelmina C M Duivenvoorden, Magda Naeim, Sarah N Hopmans, Sadiya Yousef, Geoff H Werstuck, Shawn Dason, Jehonathan H Pinthus

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Wilhelmina C M DuivenvoordenDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0003-3439-9163
Magda NaeimDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada.
Sarah N HopmansDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada.
Sadiya YousefDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada.
Geoff H WerstuckDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Shawn DasonDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada.
Jehonathan H PinthusDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada. pinthusj@hhsc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnlike in other mouse models of atherogenesis, it has recently been suggested that orchiectomy plays a role in accelerating atherosclerosis and inhibiting the progression of cardiovascular disease in the ApoE

methodsMale ApoE

resultsCastration was achieved for all three modes of ADT. However, degarelix-treated mice gained significantly less weight, had lower serum leptin levels and systolic blood pressure compared to orchiectomy and leuprolide-treated mice. ADT improved dysglycemia and atherosclerotic burden. GnRH-antagonist significantly improved survival compared to GnRH-agonist but not compared to orchiectomy.

conclusionsFurther characterization of the ApoE

Indexed as

Disease Models, AnimalProtective FactorsAndrogen AntagonistsAnimalsAntineoplastic Agents, HormonalCardiovascular DiseasesHyperglycemiaInsulinLeuprolideMaleMetabolic SyndromeMiceMice, Knockout, ApoEOligopeptidesOrchiectomyacetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamideAndrogen AntagonistsAntineoplastic Agents, HormonalIns2 protein, mouseInsulinLeuprolideOligopeptides

Identifiers

PMID32989260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.