Evidence map›Paper›PMID 32989163›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Distinct RNA

Joel D W Toh, Steven W M Crossley, Kevin J Bruemmer, Eva J Ge, Dan He, Diana A Iovan, Christopher J Chang

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 91 citations in OpenAlex.

  1. mExperimental and therapeutic medicine · 2026
    Review
  2. mMolecular medicine reports · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Targeting intracellular mRNA mJournal of advanced research · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. Decoding the role of mNeurochemistry international · 2025
    Review
  17. The crosstalk of mTrends in biochemical sciences · 2025
    Review
  18. Article
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Joel D W TohDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0003-0253-2169
Steven W M CrossleyDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0002-9932-3808
Kevin J BruemmerDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0003-3416-5615
Eva J GeDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0002-9238-1466
Dan HeDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0002-9544-5672
Diana A IovanDepartment of Chemistry, University of California, Berkeley, CA 94720.ORCID 0000-0001-9889-7183
Christopher J ChangDepartment of Chemistry, University of California, Berkeley, CA 94720; chrischang@berkeley.edu.ORCID 0000-0001-5732-9497
University of California, Berkeley · US

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MCHALE, CLIONA · 1987 to 2025
$74.6M
Chemical Probes to Study Formaldehyde BiologyR01ES028096 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2017 to 2026
$4.1M
Howard Hughes Medical InstituteNIEHS NIH HHS P42 ES004705NIEHS NIH HHS R01 ES028096
6 · The paper itself

Abstract

The AlkB family of nonheme Fe(II)/2-oxoglutarate-dependent oxygenases are essential regulators of RNA epigenetics by serving as erasers of one-carbon marks on RNA with release of formaldehyde (FA). Two major human AlkB family members, FTO and ALKBH5, both act as oxidative demethylases of

Indexed as

AlkB Homolog 5, RNA DemethylaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOBase SequenceDemethylationFatty AcidsHEK293 CellsHumansIronMCF-7 CellsModels, MolecularOxidation-ReductionProtein ConformationRNASingle-Cell AnalysisALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOFatty AcidsFTO protein, humanIronRNAformaldehydem6Anonheme iron enzymeone-carbon cycleRNA epigenetics

Identifiers

PMID32989163
PMCPMC7568336
OpenAlexW3090020170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.