Evidence map›Paper›PMID 32989159›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Characterization and engineering of a two-enzyme system for plastics depolymerization.

Brandon C Knott, Erika Erickson, Mark D Allen, Japheth E Gado, Rosie Graham, Fiona L Kearns, Isabel Pardo, Ece Topuzlu, Jared J Anderson, Harry P Austin and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 1 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 1 synthesis or guideline pooled it, 504 citations in OpenAlex.

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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Brandon C KnottRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Erika EricksonRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.ORCID 0000-0001-7806-9348
Mark D AllenCentre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, United Kingdom.
Japheth E GadoRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Rosie GrahamCentre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, United Kingdom.ORCID 0000-0001-5371-3942
Fiona L KearnsDepartment of Chemistry, University of South Florida, Tampa, FL 33620.
Isabel PardoRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Ece TopuzluRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Jared J AndersonRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Harry P AustinCentre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, United Kingdom.
Graham DominickRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Christopher W JohnsonRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.ORCID 0000-0002-2979-4751
Nicholas A RorrerRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.ORCID 0000-0001-9134-5853
Caralyn J SzostkiewiczRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401.
Valérie CopiéDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Christina M PayneDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506.
H Lee WoodcockDepartment of Chemistry, University of South Florida, Tampa, FL 33620.
Bryon S DonohoeBiosciences Center, National Renewable Energy Laboratory, Golden, CO 80401.ORCID 0000-0002-2272-5059
Gregg T BeckhamRenewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401; gregg.beckham@nrel.gov john.mcgeehan@port.ac.uk.ORCID 0000-0002-3480-212X
John E McGeehanCentre for Enzyme Innovation, School of Biological Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, United Kingdom; gregg.beckham@nrel.gov john.mcgeehan@port.ac.uk.ORCID 0000-0002-6750-1462
National Laboratory of the Rockies · USUniversity of Portsmouth · GBUniversity of South Florida · USMontana State University · USUniversity of Kentucky · US

Funding

Design and application ofrobust and efficient QM/MM free energy simulation methods for biomolecular systemsR01GM129519 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI WOODCOCK III, HENRY LEE · 2018 to 2025
$1.9M
Biotechnology and Biological Sciences Research Council BB/P011918/1NIGMS NIH HHS R01 GM129519
6 · The paper itself

Abstract

Plastics pollution represents a global environmental crisis. In response, microbes are evolving the capacity to utilize synthetic polymers as carbon and energy sources. Recently,

Indexed as

Bacterial ProteinsBurkholderialesModels, MolecularMutationPlasticsPolyethylene TerephthalatesProtein ConformationProtein DomainsProtein EngineeringSubstrate SpecificityBacterial ProteinsPlasticsPolyethylene Terephthalatesbiodegradationpolyethylene terephthalaterecyclingserine hydrolaseupcycling

Identifiers

PMID32989159
PMCPMC7568301
OpenAlexW3089916935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.