Evidence map›Paper›PMID 32989137›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in

Felipe Martelli, Zuo Zhongyuan, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusitha Rupasinghe, Kartik Venkatachalam, Trent Perry, Hugo J Bellen and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 159 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Felipe MartelliSchool of BioSciences, The University of Melbourne, Parkville, VIC, 3052, Australia.ORCID 0000-0003-4783-9025
Zuo ZhongyuanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Julia WangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-6984-8283
Ching-On WongDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102.
Nicholas E KaragasDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, TX 77030.ORCID 0000-0002-7196-8014
Ute RoessnerSchool of BioSciences, The University of Melbourne, Parkville, VIC, 3052, Australia.ORCID 0000-0002-6482-2615
Thusitha RupasingheSchool of BioSciences, The University of Melbourne, Parkville, VIC, 3052, Australia.
Kartik VenkatachalamDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, TX 77030.ORCID 0000-0002-3055-9265
Trent PerrySchool of BioSciences, The University of Melbourne, Parkville, VIC, 3052, Australia.ORCID 0000-0002-8045-0487
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-5992-5989
Philip BatterhamSchool of BioSciences, The University of Melbourne, Parkville, VIC, 3052, Australia; p.batterham@unimelb.edu.au.ORCID 0000-0001-9840-9119
The University of Melbourne · AUBaylor College of Medicine · USThe University of Texas Health Science Center at Houston · USHoward Hughes Medical Institute · USRutgers, The State University of New Jersey · US

Funding

Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositidesRF1AG069076 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2020 to 2020
$1.8M
Modulation of mitochondrial proliferation and function in Drosophila neuronsR21AG061646 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SARDIELLO, MARCO, VENKATACHALAM, KARTIK · 2018 to 2019
$443k
Involvement of an ER to lysosome signaling axis in the onset of neurodegeneration in models of ADR21AG067414 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2020 to 2020
$421k
Howard Hughes Medical InstituteNIA NIH HHS R21 AG061646NIA NIH HHS R21 AG067414NIA NIH HHS RF1 AG069076
6 · The paper itself

Abstract

Declining insect population sizes are provoking grave concern around the world as insects play essential roles in food production and ecosystems. Environmental contamination by intense insecticide usage is consistently proposed as a significant contributor, among other threats. Many studies have demonstrated impacts of low doses of insecticides on insect behavior, but have not elucidated links to insecticidal activity at the molecular and cellular levels. Here, the histological, physiological, and behavioral impacts of imidacloprid are investigated in

Indexed as

AnimalsBehavior, AnimalCalciumDrosophila melanogasterFemaleImidazolesInsecticidesLarvaMaleMitochondriaNeonicotinoidsNeuronsNitro CompoundsOxidative StressReactive Oxygen SpeciesCalciumimidaclopridImidazolesInsecticidesNeonicotinoidsNitro CompoundsReactive Oxygen Speciesimidaclopridlipid dysregulationneurodegenerationoxidative stressvision loss

Identifiers

PMID32989137
PMCPMC7568275
OpenAlexW3091461154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.