ArticleProceedings of the National Academy of Sciences of the United States of America2020
Universal motifs and the diversity of autocatalytic systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Using MR-chordless circuits for efficient enumeration of autocatalytic cores in large chemical reaction networks.Journal of cheminformatics · 2026Article
- Enumeration of Autocatalytic Subsystems in Large Chemical Reaction Networks.Journal of chemical theory and computation · 2026Article
- Autocatalytic cores in the diluted regime: classification and properties.Journal of mathematical biology · 2026Article
- Comprehensive Mapping of Compositional Dynamics in the Formose Reaction Network.Angewandte Chemie (International ed. in English) · 2026Article
- Is the emergence of life and of agency expected?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- How hard is it to encapsulate life? The general constraints on encapsulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Thermodynamics of Darwinian selection in molecular replicators.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Evolutionary features in a minimal physical system: Diversity, selection, growth, inheritance, and adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multilayered substructures of a non-enzymatic chemical reaction network for synthesizing sugars.Communications chemistry · 2025Article
- Thermodynamic consistency of autocatalytic cycles.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multi-Layer Autocatalytic Feedback Enables Integral Control Amidst Resource Competition and Across Scales.ACS synthetic biology · 2025Article
- The Nature of Organization in Living Systems.ArXiv · 2025Article
- Spatial structure supports diversity in prebiotic autocatalytic chemical ecosystems.Npj complexity · 2025Article
- Design principles, growth laws, and competition of minimal autocatalysts.Communications chemistry · 2024Article
- Autocatalytic Sets and Assembly Theory: A Toy Model Perspective.Entropy (Basel, Switzerland) · 2024Article
- Self-generating autocatalytic networks: structural results, algorithms and their relevance to early biochemistry.Journal of the Royal Society, Interface · 2024Article
- Primitive purine biosynthesis connects ancient geochemistry to modern metabolism.Nature ecology & evolution · 2024Article
- Small-molecule autocatalysis drives compartment growth, competition and reproduction.Nature chemistry · 2024Article
- Multistable Protocells Can Aid the Evolution of Prebiotic Autocatalytic Sets.Life (Basel, Switzerland) · 2023Article
- On the Emergence of Autonomous Chemical Systems through Dissipation Kinetics.Life (Basel, Switzerland) · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autocatalysis is essential for the origin of life and chemical evolution. However, the lack of a unified framework so far prevents a systematic study of autocatalysis. Here, we derive, from basic principles, general stoichiometric conditions for catalysis and autocatalysis in chemical reaction networks. This allows for a classification of minimal autocatalytic motifs called cores. While all known autocatalytic systems indeed contain minimal motifs, the classification also reveals hitherto unidentified motifs. We further examine conditions for kinetic viability of such networks, which depends on the autocatalytic motifs they contain and is notably increased by internal catalytic cycles. Finally, we show how this framework extends the range of conceivable autocatalytic systems, by applying our stoichiometric and kinetic analysis to autocatalysis emerging from coupled compartments. The unified approach to autocatalysis presented in this work lays a foundation toward the building of a systems-level theory of chemical evolution.
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