Evidence map›Paper›PMID 32989125›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Proteome-wide effects of naphthalene-derived secondary organic aerosol in BEAS-2B cells are caused by short-lived unsaturated carbonyls.

Jiajun Han, Shunyao Wang, Kirsten Yeung, Diwen Yang, Wen Gu, Zhiyuan Ma, Jianxian Sun, Xiaomin Wang, Chung-Wai Chow, Arthur W H Chan and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Toxicological Effects of Secondary Air Pollutants.Chemical research in Chinese universities · 2023
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jiajun HanDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.ORCID 0000-0002-8597-6971
Shunyao WangDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.ORCID 0000-0002-1245-0119
Kirsten YeungDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Diwen YangDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Wen GuDepartment of Environmental Toxicology, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Zhiyuan MaState Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
Jianxian SunDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Xiaomin WangDivision of Respirology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
Chung-Wai ChowDivision of Respirology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.
Arthur W H ChanDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada; arthurwh.chan@utoronto.ca hui.peng@utoronto.ca.ORCID 0000-0001-7392-4237
Hui PengDepartment of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada; arthurwh.chan@utoronto.ca hui.peng@utoronto.ca.
University of Toronto · CAChinese Center For Disease Control and Prevention · CNState Key Laboratory of Pollution Control and Resource Reuse · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to air pollution causes adverse health outcomes, but the toxicity mechanisms remain unclear. Here, we investigated the dynamic toxicities of naphthalene-derived secondary organic aerosol (NSOA) in a human bronchial epithelial cell line (BEAS-2B) and identified the chemical components responsible for toxicities. The chemical composition of NSOA was found to vary with six simulated atmospheric aging conditions (C

Indexed as

AerosolsCell LineDown-RegulationGene Expression RegulationHumansMolecular StructureNaphthalenesNF-E2-Related Factor 2Protein Processing, Post-TranslationalProteomeProteomicsUp-RegulationAerosolsnaphthaleneNaphthalenesNFE2L2 protein, humanNF-E2-Related Factor 2Proteomeatmospheric agingcysteine alkylationNrf2-Keap1proteomicstoxicity dynamics

Identifiers

PMID32989125
PMCPMC7568281
OpenAlexW3091312245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.