Evidence map›Paper›PMID 32989050›Full record

ArticleThe Journal of biological chemistry2020

Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways.

Liwen Liang, Huili Li, Ting Cao, Lina Qu, Lulu Zhang, Guo-Chang Fan, Peter A Greer, Jianmin Li, Douglas L Jones, Tianqing Peng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

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  11. Technology using simulated microgravity.Regenerative therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Liwen LiangInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Huili LiInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Ting CaoInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Lina QuState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China. Electronic address: linaqu@263.net.
Lulu ZhangInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Guo-Chang FanDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Peter A GreerDivision of Cancer Biology and Genetics, Queen's University Cancer Research Institute, Queen's University, Kingston, Ontario, Canada; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Jianmin LiDepartment of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Douglas L JonesDepartment of Physiology and Pharmacology, Western University, London, Ontario, Canada; Lawson Health Research Institute of London Health Sciences Centre, London, Ontario, Canada; Department of Medicine, Western University, London, Ontario, Canada.
Tianqing PengInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Lawson Health Research Institute of London Health Sciences Centre, London, Ontario, Canada; Department of Medicine, Western University, London, Ontario, Canada. Electronic address: tqpeng@suda.edu.cn.
Soochow University · CNWestern University · CAChina Astronaut Research and Training Center · CNQueen's University · CAUniversity of Cincinnati Medical Center · USWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of

Indexed as

MAP Kinase Signaling SystemWeightlessnessAnimalsCalpainHeartHindlimb SuspensionMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MyocardiumMyocytes, CardiacNADPH OxidasesOrgan SizeCalpainCapns1 protein, mouseMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NADPH Oxidasesneutrophil cytosolic factor 1p38 Mitogen-Activated Protein KinasescalpaincardiomyocyteERK1/2heartmicrogravitymitogen-activated protein kinase (MAPK)myocardial abnormalitiesNADPH oxidasep38

Identifiers

PMID32989050
PMCPMC7864076
OpenAlexW3091565847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.