Evidence map›Paper›PMID 32989037›Full record

ArticleInfection and immunity2020

Identification of Autophagy-Inhibiting Factors of Mycobacterium tuberculosis by High-Throughput Loss-of-Function Screening.

Emily J Strong, Kristen L Jurcic Smith, Neeraj K Saini, Tony W Ng, Steven A Porcelli, Sunhee Lee

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 36 citations in OpenAlex.

  1. Epigenetic Reprogramming byAntibiotics (Basel, Switzerland) · 2026
    Review
  2. A Case of Transmission of Bedaquiline- and Linezolid-Resistant Tuberculosis.International journal of molecular sciences · 2026
    Article
  3. The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. The Role of mTOR inBiomedicines · 2024
    Review
  12. Functional Analysis of Genes inIndian journal of microbiology · 2024
    Review
  13. Frontiers in tuberculosis · 2024
    Article
  14. Review
  15. Virulence · 2023
    Article
  16. Article
  17. Review
  18. Frontiers in cellular and infection microbiology · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Emily J StrongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Kristen L Jurcic SmithHuman Vaccine Institute, Duke University, Durham, North Carolina, USA.
Neeraj K SainiDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Tony W NgDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Steven A PorcelliDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Sunhee LeeDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA sunhlee@utmb.edu.ORCID 0000-0002-2599-6938
Albert Einstein College of Medicine · USDuke University · USThe University of Texas Medical Branch at Galveston · US

Funding

Modulation of Host Cell Environment by Mycobacterial PE/PPE ProteinsR01AI127711 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LEE, SUNHEE, PORCELLI, STEVEN A · 2017 to 2021
$2.8M
NIAID NIH HHS R01 AI127711
6 · The paper itself

Abstract

The interaction of host cells with mycobacteria is complex and can lead to multiple outcomes ranging from bacterial clearance to progressive or latent infection. Autophagy is recognized as one component of host cell responses that has an essential role in innate and adaptive immunity to intracellular bacteria. Many microbes, including

Indexed as

AutophagyAnimalsBacterial ProteinsDrug Resistance, BacterialGene LibraryHigh-Throughput Screening AssaysHost Microbial InteractionsImmunity, InnateInterleukin-1betaMacrophagesMiceMycobacterium smegmatisMycobacterium tuberculosisRAW 264.7 CellsTOR Serine-Threonine KinasesTuberculosisBacterial ProteinsInterleukin-1betaTOR Serine-Threonine KinasesTumor Necrosis Factor-alphaVirulence Factorsautophagyhigh-throughput screenhost-pathogen interactionsinnate immunityintracellular growthMycobacterium tuberculosisPE/PPE proteins

Identifiers

PMID32989037
PMCPMC7671894
OpenAlexW3091120061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.