Evidence map›Paper›PMID 32988966›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2020

DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection.

Charles A Ishak, Daniel D De Carvalho

Abstract readComment
PubMed Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Charles A IshakPrincess Margaret Cancer Centre, University Health Network. Toronto, Ontario, Canada.
Daniel D De CarvalhoPrincess Margaret Cancer Centre, University Health Network. Toronto, Ontario, Canada. daniel.decarvalho@uhnresearch.ca.

Funding

CIHR 201512MSH-360794-228629CIHR MFE-164724CIHR PJT-165986
6 · The paper itself

Abstract

Genome-wide DNA methylation profiles of serous tubal intraepithelial carcinomas (STIC) resemble methylation profiles of high-grade serous ovarian carcinomas (HGSOC) more closely than normal fallopian tube epithelium. While STICs and HGSOCs share subsets of common hypermethylated regions, DNA methylation can distinguish STICs from HGSOCs to provide proof-of-principle that DNA methylation can identify HGSOC initiation.

Indexed as

Cystadenocarcinoma, SerousFallopian Tube NeoplasmsOvarian NeoplasmsCarcinoma, Ovarian EpithelialDNA MethylationEarly Detection of CancerFemaleHumans

Identifiers

PMID32988966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.