Evidence map›Paper›PMID 32988822›Full record

Trial reportAntimicrobial agents and chemotherapy2020

A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during

Johan Courjon, Margaux Garzaro, Pierre-Marie Roger, Raymond Ruimy, Thibaud Lavrut, Mikaël Chelli, Jean-Luc Raynier, David Chirio, Elisa Demonchy, Laura Cabane and 4 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03246360 (Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin During Bone and Joint Infections), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03246360 nacompletednot on this map

Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin During Bone and Joint Infections: a Prospective, Randomized, Open-label, Monocentric Crossover Study.

TypeinterventionalSponsorCentre Hospitalier Universitaire de NiceRan2017 to 2018Enrolled12ConditionsInfection, Methicillin Susceptible Staphylococcus Aureus Infection, Cloxacillin TreatmentArmsModification for administration mode of cloxacillin antibiotic
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Johan Courjon *Université Côte d'Azur, CHU Nice, Infectiologie, Nice, France courjon.j@chu-nice.fr.ORCID 0000-0002-0445-5104
Margaux Garzaro *Université Côte d'Azur, CHU Nice, Infectiologie, Nice, France.
Pierre-Marie RogerInfectiologie, CHU de Pointe-à-Pitre, Pointe-à-Pitre, France.
Raymond RuimyUniversité Côte d'Azur, CHU, INSERM, C3M, Nice, France.
Thibaud LavrutPharmacologie, Hôpital Pasteur, Centre Hospitalier Universitaire de Nice, Nice, France.
Mikaël ChelliService de Chirurgie Orthopédique et Chirurgie du Sport, Institut Universitaire Locomoteur et du Sport, Hôpital Pasteur 2, CHU Nice, Nice, France.
Jean-Luc RaynierService de Chirurgie Orthopédique et Chirurgie du Sport, Institut Universitaire Locomoteur et du Sport, Hôpital Pasteur 2, CHU Nice, Nice, France.
David ChirioUniversité Côte d'Azur, CHU Nice, Infectiologie, Nice, France.ORCID 0000-0002-7186-2818
Elisa DemonchyUniversité Côte d'Azur, CHU Nice, Infectiologie, Nice, France.
Laura CabaneRhumatologie, Hôpital Pasteur 2, CHU Nice, Nice, France.
François JehlFédération de Médecine Translationnelle de Strasbourg, EA7290 Virulence Bactérienne Précoce, CHRU Strasbourg, Institut de Bactériologie, Université de Strasbourg, Strasbourg, France.
Christophe TrojaniUniversité Côte d'Azur, Nice, France.
Antoine GrillonFédération de Médecine Translationnelle de Strasbourg, EA7290 Virulence Bactérienne Précoce, CHRU Strasbourg, Institut de Bactériologie, Université de Strasbourg, Strasbourg, France.
Sylvain GoutelleHospices Civils de Lyon, Groupement Hospitalier Nord, Service de Pharmacie, Lyon, France.ORCID 0000-0002-1853-2932
Université Côte d'Azur · FRHôpital Pasteur · FRHôpitaux Universitaires de Strasbourg · FRInserm · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous administration of antibiotics is recommended during the early phase of methicillin-susceptible

Indexed as

CloxacillinStaphylococcus aureusAnti-Bacterial AgentsHumansInfusions, IntravenousMicrobial Sensitivity TestsProspective StudiesAnti-Bacterial AgentsCloxacillinantibioticsbone and joint infectionscloxacillincontinuous infusionosteomyelitispenicillinpharmacodynamicpharmacokineticspopulation pharmacokineticspopulation PK analysisStaphylococcus aureus

Identifiers

PMID32988822
PMCPMC7674037
OpenAlexW3090778436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.