Evidence map›Paper›PMID 32988369›Full record

Trial reportBMC anesthesiology2020

Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial.

Rui Xu, Yun Zhu, Yi Lu, Wenxian Li, Jie Jia

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03918889 (A Randomized Controlled Trial of the Effect of Dexmedetomidine Compared With Midazolam on Airway Reflex and Recovery Quality During Emergence From General Anesthesia After Partial and Total Laryngectomy), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03918889 naunknown statusnot on this map

A Randomized Controlled Trial of the Effect of Dexmedetomidine Compared With Midazolam on Airway Reflex and Recovery Quality During Emergence From General Anesthesia After Partial and Total Laryngectomy

TypeinterventionalSponsorEye & ENT Hospital of Fudan UniversityRan2019 to 2020Enrolled120ConditionsLaryngectomy, StatusArmsDexmedetomidine Injectable Product, Midazolam injection
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Impact of implemented strategies on survival and complications in laryngectomized patients: a retrospective cohort study from an oncology reference center.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rui XuDepartment of Anesthesiology, The Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai Medical College of Fudan University, Fenyang Road #83, Shanghai, 200031, People's Republic of China.
Yun ZhuDepartment of Oro-maxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Yi LuDepartment of Anesthesiology, The Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai Medical College of Fudan University, Fenyang Road #83, Shanghai, 200031, People's Republic of China.
Wenxian LiDepartment of Anesthesiology, The Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai Medical College of Fudan University, Fenyang Road #83, Shanghai, 200031, People's Republic of China. liwenxian@eentanesthesia.com.
Jie JiaDepartment of Anesthesiology, The Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai Medical College of Fudan University, Fenyang Road #83, Shanghai, 200031, People's Republic of China. jiajie@eentanesthesia.com.ORCID 0000-0002-6199-7823
Shanghai Medical College of Fudan University · CNShanghai Jiao Tong University · CN

Funding

fund of fudan university eye, ear and nose hospital SYB202011
6 · The paper itself

Abstract

backgroundDuring emergence from anesthesia after partial and total laryngectomy, excessive airway reflex and systemic hypertension may lead to subcutaneous emphysema, hemorrhage or pneumothorax.

methodsAmerican Society of Anesthesiologist physical status III and IV male adults undergoing elective laryngectomy were recruited and randomly allocated to receive either dexmedetomidine (group D) or midazolam (group M). The primary outcome was incidence and severity of cough. Pulse oximetry results (SpO

resultsThe prevalence of no coughing was significantly higher in group D than in group M at the points of wakefulness and departure. HR, SBP, and DBP were significantly lower in group D compared with group M, and SpO

conclusionsCompared with midazolam, dexmedetomidine is an effective alternative to attenuate coughing and hemodynamic changes with a low incidence of adverse events during emergence from anesthesia after partial and total laryngectomy.

trial registrationNCT03918889 , registered at clinicaltrials.gov, date of registration: March 28, 2019.

Indexed as

Anesthesia Recovery PeriodAdultAgedCoughDexmedetomidineDouble-Blind MethodHumansHypnotics and SedativesLaryngectomyMaleMidazolamMiddle AgedPostoperative ComplicationsProspective StudiesDexmedetomidineHypnotics and SedativesMidazolamDexmedetomidineLaryngectomyMidazolamRecovery quality

Identifiers

PMID32988369
PMCPMC7523379
OpenAlexW3088093555

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.