Evidence map›Paper›PMID 32988220›Full record

ArticleHuman gene therapy2020

Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency.

Carlo Rossi, Mark Lees, Vedanta Mehta, Tommi Heikura, John Martin, Ian Zachary, Rebecca Spencer, Donald M Peebles, Robert Shaw, Minna Karhinen and 2 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Human gene therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Angiogenic Doping: Plausible Yet Difficult to Detect.Sports medicine (Auckland, N.Z.) · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Genetics Etiologies Associated with Fetal Growth Restriction.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Review
  8. Growth Factors VEGF-AInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Carlo RossiElizabeth Garrett Anderson Institute for Women's Health.
Mark LeesElizabeth Garrett Anderson Institute for Women's Health.
Vedanta MehtaCentre for Cardiovascular Biology and Medicine; University College London, London, United Kingdom.
Tommi HeikuraA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
John MartinCentre for Cardiovascular Biology and Medicine; University College London, London, United Kingdom.
Ian ZacharyCentre for Cardiovascular Biology and Medicine; University College London, London, United Kingdom.
Rebecca SpencerElizabeth Garrett Anderson Institute for Women's Health.
Donald M PeeblesElizabeth Garrett Anderson Institute for Women's Health.
Robert ShawFinVector Oy, Kuopio, Finland.
Minna KarhinenFinVector Oy, Kuopio, Finland.
Seppo Yla-HerttualaA.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Anna L DavidElizabeth Garrett Anderson Institute for Women's Health.
Institute for Women's Policy Research · USUniversity College London · GBFinVector (Finland) · FIUniversity of Eastern Finland · FI

Funding

Department of Health
6 · The paper itself

Abstract

Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental insufficiency is a major cause. Transduction of uterine arteries in normal or FGR sheep and guinea pigs using an adenovirus (Ad) encoding

Indexed as

AdenoviridaeAnimalsDependovirusEndothelium, VascularFemaleGenetic TherapyGenetic VectorsGuinea PigsHumansHuman Umbilical Vein Endothelial CellsPlacental InsufficiencyPregnancyRabbitsSheepVascular Endothelial Growth Factor AVascular Endothelial Growth Factor AVEGFA protein, humanadenovirusendothelial cellsgene transferVEGF

Identifiers

PMID32988220
PMCPMC7698978
OpenAlexW3091154924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.