Evidence map›Paper›PMID 32987941›Full record

ArticleToxins2020

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells.

Jonathan Mackowiak da Fonseca, Ivone Izabel Mackowiak da Fonseca, Marcia Kazumi Nagamine, Cristina de Oliveira Massoco, Adriana Tomoko Nishiya, Jerrold Michael Ward, Shihui Liu, Stephen Howard Leppla, Thomas Henrik Bugge, Maria Lucia Zaidan Dagli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jonathan Mackowiak da FonsecaDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, SP, Brazil.
Ivone Izabel Mackowiak da FonsecaDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, SP, Brazil.
Marcia Kazumi NagamineDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, SP, Brazil.
Cristina de Oliveira MassocoDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, SP, Brazil.
Adriana Tomoko NishiyaDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, SP, Brazil.
Jerrold Michael WardGlobal Vet Pathology, Montgomery Village, MD 20886, USA.
Shihui LiuAging Institute and Division of Infectious Diseases, Department of Medicine, University of Pittsburg, Pittsburgh, PA 15261, USA.
Stephen Howard LepplaMicrobial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Thomas Henrik BuggeProteases & Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA.
Maria Lucia Zaidan DagliDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, SP, Brazil.ORCID 0000-0001-7031-6711
Universidade de São Paulo · BRGlobal VetPathology · USNational Institute of Dental and Craniofacial Research · USNational Institutes of Health · USPittsburg State University · US

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/16776-3
6 · The paper itself

Abstract

Canine and human osteosarcomas (OSA) share similarities. Novel therapies are necessary for these tumours. The

Indexed as

AdolescentAnimalsAntigens, BacterialAntineoplastic AgentsApoptosisBacterial ToxinsBone NeoplasmsCell Line, TumorCell MovementDogsDose-Response Relationship, DrugFemaleG1 Phase Cell Cycle CheckpointsHumansInhibitory Concentration 50Maleanthrax toxinAntigens, BacterialAntineoplastic AgentsBacterial ToxinsMatrix MetalloproteinasesMembrane ProteinsPLAU protein, humananthraxapoptosisBacillus anthraciscanine osteosarcomatoxin

Identifiers

PMID32987941
PMCPMC7601267
OpenAlexW3089100776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.