Evidence map›Paper›PMID 32987910›Full record

ArticleNutrients2020

Protective Effects of ALDH1A Enzyme Inhibition on

Audrey Seamons, Michael Haenisch, Stacey Meeker, Olesya Pershutkina, Thea Brabb, Piper M Treuting, Jisun Paik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. BioMed research international · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Audrey SeamonsDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-2609-1230
Michael HaenischDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Stacey MeekerDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Olesya PershutkinaDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Thea BrabbDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Piper M TreutingDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-1812-1519
Jisun PaikDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.

Funding

Inhibition of ALDH1A1 for the treatment of obesityR56DK110239 · NIDDK · UNIVERSITY OF WASHINGTON · PI PAIK, JISUN · 2017 to 2018
$622k
Vitamin D mediated protection in inflammatory bowel diseaseK01OD021420 · OD · UNIVERSITY OF WASHINGTON · PI MEEKER, STACEY MARIE · 2016 to 2019
$592k
NIDDK NIH HHS R56 DK110239NIH HHS K01OD021420NIH HHS R56DK110239-01A1
6 · The paper itself

Abstract

Many inflammatory bowel disease (IBD) patients require surgical intervention due to limited pharmacological treatment options. Antibodies targeting α4ß7, a gut-homing integrin, are one of the most promising IBD treatments. As retinoic acid (RA) regulates expression of gut-homing proteins including α4ß7 integrin, we tested if ALDH1A enzymes in the RA synthesis pathway could be targeted for IBD treatment using a potent inhibitor, WIN 18,446. Age- and sex-matched

Indexed as

Aldehyde Dehydrogenase 1 FamilyAnimalsColitisDiaminesDisease Models, AnimalFemaleHelicobacterHelicobacter InfectionsIntegrin alpha4Lymphocyte ActivationMaleMiceMice, Inbred C57BLMice, KnockoutRetinal DehydrogenaseAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, mouseDiaminesIntegrin alpha4N,N'-bis(dichloroacetyl)-1,8-octamethylenediamineRetinal DehydrogenaseALDH1A enzymesimmunityinflammatory bowel diseasemouse modelretinoic acid

Identifiers

PMID32987910
PMCPMC7599670

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.