ArticleBiomolecules2020
Recovery of Bioactive Compounds from Hazelnuts and Walnuts Shells: Quantitative-Qualitative Analysis and Chromatographic Purification.
Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Interaction of Hazelnut-Derived Polyphenols with Biodegradable Film Matrix: Structural, Barrier, and Functional Properties.Foods (Basel, Switzerland) · 2025Article
- Ultrasound-assisted extraction of phenolic compounds from walnut (Juglans regia L.) shell waste using choline chloride-based natural deep eutectic solvents (NADES): an in vitro bioaccessibility study.Journal of the science of food and agriculture · 2025Article
- Biorefining of Walnut Shells into Polyphenol-Rich Extracts Using Ultrasound-Assisted, Enzyme-Assisted, and Pressurized Liquid Extraction Coupled with Chemometrics.Foods (Basel, Switzerland) · 2025Article
- Hazelnut and Walnut Nutshell Features as Emerging Added-Value Byproducts of the Nut Industry: A Review.Plants (Basel, Switzerland) · 2024Review
- 'Sorrento' and 'Tulare' Walnut Cultivars: Morphological Traits and Phytochemical Enhancement of Their Shell Waste.Molecules (Basel, Switzerland) · 2024Article
- GreenHeliyon · 2024Article
- Unveiling the "hidden quality" of the walnut pellicle: a precious source of bioactive lipids.Frontiers in plant science · 2024Article
- Superior Valorisation ofMolecules (Basel, Switzerland) · 2023Article
- The Effect of Milling on the Ethanolic Extract Composition of Dried Walnut (International journal of molecular sciences · 2023Article
- Effect ofFrontiers in physiology · 2023Article
- A critical look at challenges and future scopes of bioactive compounds and their incorporations in the food, energy, and pharmaceutical sector.Environmental science and pollution research international · 2022Review
- Analysis, Development, and Scaling-Up of Poly(lactic acid) (PLA) Biocomposites with Hazelnuts Shell Powder (HSP).Polymers · 2021Article
- Hazelnut Shells as Source of Active Ingredients: Extracts Preparation and Characterization.Molecules (Basel, Switzerland) · 2021Article
- An Integrated Approach for the Valorization of Sea Bass (Foods (Basel, Switzerland) · 2021Article
- Biomolecules from Plant Residues.Biomolecules · 2020Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Hazelnut (HS) and walnut (WS) shells, an abundant by-product of the processing industries of these edible nuts, are traditionally considered as a low-value waste. However, they are a source of valuable compounds with an interesting chemical profile for the chemical and pharmaceutical sectors. In this study, the lipophilic and hydrophilic extracts present in HS and WS were quantified and identified, then the polar fractions were chromatographically separated, and their antioxidant capacity was studied. The experimental work includes the isolation of crude lipophilic and hydrophilic extracts by an accelerated extraction process, chromatographic analysis (gas chromatography-flame ionization (GC-FID), GC-mass spectroscopy (GC-MS), high-performance size-exclusion chromatography (HPSEC), thin-layer chromatography (TLC)), and quantification of the components. In addition, a thorough compositional characterization of the subgroups obtained by flash chromatography and their antioxidant capacity was carried out. The gravimetric concentrations showed different lipophilic/hydrophilic ratios (0.70 for HS and 0.23 for WS), indicating a higher proportion of polar compounds in WS than in HS. Moreover, the lipophilic extracts were principally composed of short-chain fatty acids (stearic, palmitic, and oleic acid), triglycerides, and sterols. The polar fractions were screened by thin-layer chromatography and then separated by flash chromatography, obtaining fractions free of fatty acids and sugar derivatives (97:3 in HS and 95:5 in WS), and mixtures richer in phenolic compounds and flavonoids such as guaiacyl derivatives, quercetin, pinobanksin, and catechin. The most polar fractions presented a higher antioxidant capacity than that of the crude extracts.
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Registered trials
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