Evidence map›Paper›PMID 32987703›Full record

ArticleInternational journal of molecular sciences2020

Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome.

Felke Steijns, Marjolijn Renard, Marine Vanhomwegen, Petra Vermassen, Jana Desloovere, Robrecht Raedt, Lars E Larsen, Máté I Tóth, Julie De Backer, Patrick Sips

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Skeletal muscle alterations in Marfan syndrome: a systematic review.Journal of muscle research and cell motility · 2025
    Pooled it
  2. Article
  3. Article
  4. Cardiomyopathy in Genetic Aortic Diseases.Frontiers in pediatrics · 2021
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Felke SteijnsCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Marjolijn RenardCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Marine VanhomwegenCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Petra VermassenCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.
Jana Desloovere4BRAIN, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0003-4261-3983
Robrecht Raedt4BRAIN, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-8939-0169
Lars E Larsen4BRAIN, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium.
Máté I TóthInstitute Biomedical Technology, Ghent University, 9000 Ghent, Belgium.
Julie De BackerCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-8878-1507
Patrick SipsCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0001-9241-5980
Ghent University Hospital · BEGhent University · BE

Funding

Bijzonder Onderzoeksfonds UGent 01M01108Fonds voor hartchirurgie 489644Fonds Wetenschappelijk Onderzoek Postdoctoral scholarship Marjolijn RenardFonds Wetenschappelijk Onderzoek Senior Clinical Investigator scholarship Julie De BackerH2020 Marie Skłodowska-Curie Actions 794365
6 · The paper itself

Abstract

Patients with Marfan syndrome (MFS), a connective tissue disorder caused by pathogenic variants in the gene encoding the extracellular matrix protein fibrillin-1, have an increased prevalence of primary cardiomyopathy, arrhythmias, and sudden cardiac death. We have performed an in-depth in vivo and ex vivo study of the cardiac phenotype of

Indexed as

Marfan SyndromeAdipokinesAneurysm, FalseAnimalsDisease Models, AnimalFibrillin-1HeartHeart RateMaleMiceMice, Inbred C57BLMyocardiumPhenotypeVentricular FunctionAdipokinesFbn1 protein, mouseFibrillin-1arrhythmiacardiac functionelectrocardiogramfibrillin-1marfan syndromemyocardial compactionventricular pseudoaneurysm

Identifiers

PMID32987703
PMCPMC7582482
OpenAlexW3088318365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.