Evidence map›Paper›PMID 32987658›Full record

ArticleBiosensors2020

Tuning the Surface Charge of Self-Assembled Polydiacetylene Vesicles to Control Aggregation and Cell Binding.

Anthony David Nelson, Priyanka Shiveshwarkar, Butaek Lim, Gumaro Rojas, Izele Abure, Anura Shrestha, Justyn Jaworski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anthony David NelsonDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA.
Priyanka ShiveshwarkarDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA.
Butaek LimDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA.ORCID 0000-0002-9027-0308
Gumaro RojasDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA.
Izele AbureDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA.
Anura ShresthaDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA.
Justyn JaworskiDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76013, USA.

Funding

Development of novel liposome-based assays for quantifying anti-glycan antibody levels in serumR15GM135892 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI JAWORSKI, JUSTYN · 2019 to 2019
$373k
NIGMS NIH HHS R15 GM135892NIGMS NIH HHS R15GM135892
6 · The paper itself

Abstract

Polydiacetylene vesicles of various compositions were assembled using a two-part mixture of 10,12-pentacosadiynoic acid (PCDA) and ethylenedioxy-bis-ethylamine (EDEA)-labeled PCDA in order to control surface charge and stability within a desired pH range. Investigation of the interaction of the vesicles with mammalian cells as a function of surface charge was carried out and identified a clear correlation in cell-vesicle association and corresponding cell death for vesicles with positive surface charge. The binding behavior of the vesicles was found to be tunable by regulating the proportion of anionic PCDA relative to cationic PCDA-EDEA content within vesicles as to control the surface charge as a function of pH. Association of vesicles with cells thus depended on the corresponding charge of the vesicles and cell surface. The prospect of this work may serve as a step toward future vesicle designs to allow triggered uptake of vesicles locally within low pH tumor microenvironments.

Indexed as

Biosensing TechniquesPolyacetylene PolymerAnimalsHumansMammalsPhospholipidsPolymersPhospholipidsPolyacetylene PolymerpolydiacetylenePolymerspHpolydiacetylenesurface chargevesicles

Identifiers

PMID32987658
PMCPMC7598607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.