ArticleNeuroImage. Clinical2020
Reduced structural connectivity in cortico-striatal-thalamic network in neonates with congenital heart disease.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- Functional network organization is locally atypical in children, adolescents, and young adults with congenital heart disease.NeuroImage. Clinical · 2026Article
- Maternal Socioeconomic Opportunity and Race-Ethnicity Intersect to Influence Fetal Brain Volumes in Congenital Heart Disease.Journal of the American Heart Association · 2025Article
- Methodological considerations on diffusion MRI tractography in infants aged 0-2 years: a scoping review.Pediatric research · 2025Article
- Altered Connectome Topology in Newborns at Risk for Cognitive Developmental Delay: A Cross-Etiologic Study.Human brain mapping · 2025Article
- The cumulative impact of clinical risk on brain networks and associations with executive function impairments in adolescents with congenital heart disease.Human brain mapping · 2024Article
- Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease.Journal of clinical medicine · 2024Article
- Characterizing normal perinatal development of the human brain structural connectivity.Human brain mapping · 2024Article
- Postnatal Brain Trajectories and Maternal Intelligence Predict Childhood Outcomes in Complex CHD.Journal of clinical medicine · 2024Article
- Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study.Diagnostics (Basel, Switzerland) · 2023Article
- Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease.Translational pediatrics · 2023Review
- Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study.medRxiv : the preprint server for health sciences · 2023Article
- Applications of advanced diffusion MRI in early brain development: a comprehensive review.Brain structure & function · 2023Review
- Altered white matter connectivity in children with congenital heart disease with single ventricle physiology.Scientific reports · 2023Article
- Impact of cardiac surgical timing on the neurodevelopmental outcomes of newborns with Complex congenital heart disease (CHD).Frontiers in pediatrics · 2023Article
- Reduced Cerebellar Volume in Term Infants with Complex Congenital Heart Disease: Correlation with Postnatal Growth Measurements.Diagnostics (Basel, Switzerland) · 2022Article
- Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes.Pediatric research · 2022Review
- Clinical factors associated with microstructural connectome related brain dysmaturation in term neonates with congenital heart disease.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 4 countries.
Funding
Abstract
Impaired brain development has been observed in newborns with congenital heart disease (CHD). We performed graph theoretical analyses and network-based statistics (NBS) to assess global brain network topology and identify subnetworks of altered connectivity in infants with CHD prior to cardiac surgery. Fifty-eight infants with critical/serious CHD prior to surgery and 116 matched healthy controls as part of the developing Human Connectome Project (dHCP) underwent MRI on a 3T system and high angular resolution diffusion MRI (HARDI) was obtained. Multi-tissue constrained spherical deconvolution, anatomically constrained probabilistic tractography (ACT) and spherical-deconvolution informed filtering of tractograms (SIFT2) was used to construct weighted structural networks. Network topology was assessed and NBS was used to identify structural connectivity differences between CHD and control groups. Structural networks were partitioned into core and peripheral nodes, and edges classed as core, peripheral, or feeder. NBS identified one subnetwork with reduced structural connectivity in CHD infants involving basal ganglia, amygdala, hippocampus, cerebellum, vermis, and temporal and parieto-occipital lobe, primarily affecting core nodes and edges. However, we did not find significantly different global network characteristics in CHD neonates. This locally affected sub-network with reduced connectivity could explain, at least in part, the neurodevelopmental impairments associated with CHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.