ArticleNeuroImage. Clinical2020
Reproducible metabolic topographies associated with multiple system atrophy: Network and regional analyses in Chinese and American patient cohorts.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Cerebral metabolic trajectories alterations in multiple system atrophy: A longitudinal FDG-PET study.Journal of Parkinson's disease · 2026Article
- Different brain spatial metabolic patterns characterizing different subtypes of multiple system atrophy.Journal of Parkinson's disease · 2026Article
- The role of neuro-imaging in multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Molecular imaging based spatiotemporal dynamics progression of brain glucose metabolism in multiple system atrophy.European journal of nuclear medicine and molecular imaging · 2026Article
- A Review of FDG-PET in Progressive Supranuclear Palsy and Corticobasal Syndrome.International journal of molecular sciences · 2025Review
- Positron Emission Tomography Imaging in Clinical Trials for Parkinson's Disease: Applications of Metabolic Brain Network Approach.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- International consensus on clinical use of presynaptic dopaminergic positron emission tomography imaging in parkinsonism.European journal of nuclear medicine and molecular imaging · 2024Article
- Functional Brain Networks to Evaluate Treatment Responses in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- The identification and cognitive correlation of perfusion patterns measured with arterial spin labeling MRI in Alzheimer's disease.Alzheimer's research & therapy · 2023Article
- Disease specific and nonspecific metabolic brain networks in behavioral variant of frontotemporal dementia.Human brain mapping · 2023Article
- Adjustment for the Age- and Gender-Related Metabolic Changes Improves the Differential Diagnosis of Parkinsonism.Phenomics (Cham, Switzerland) · 2023Article
- Functional brain networks in the evaluation of patients with neurodegenerative disorders.Nature reviews. Neurology · 2023Review
- Large-scale activation likelihood estimation meta-analysis of parkinsonian disorders.Brain communications · 2023Article
- Longitudinal Changes in Isolated Rapid Eye Movement Sleep Behavior Disorder-Related Metabolic Pattern Expression.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders.Bioelectronic medicine · 2021Review
- Cerebral Metabolism Related to Cognitive Impairments in Multiple System Atrophy.Frontiers in neurology · 2021Article
- Evaluation of Multiple System Atrophy Subtypes with FDG-PET.Annals of Indian Academy of NeurologyArticle
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeMultiple system atrophy (MSA) is an atypical parkinsonian syndrome and often difficult to discriminate clinically from progressive supranuclear palsy (PSP) and Parkinson's disease (PD) in early stages. Although a characteristic metabolic brain network has been reported for MSA, it is unknown whether this network can provide a clinically useful biomarker in different centers. This study was aimed to identify and cross-validate MSA-related brain network and assess its ability for differential diagnosis and clinical correlations in Chinese and American patient cohorts.
methodsWe included
resultsWe generated a highly reliable MSAPRP characterized by decreased loading in inferior frontal cortex, striatum and cerebellum, and increased loading in sensorimotor, parietal and occipital cortices. MSAPRP scores discriminated between normal, MSA, PSP and PD subjects and correlated with standardized ratings of clinical stages and motor symptoms in MSA. High similarities in MSAPRPs, network scores and corresponding maps of metabolic abnormality were observed between two different cohorts.
conclusionWe have demonstrated reproducible metabolic topographies associated with MSA at both network and regional levels in two independent patient cohorts. Moreover, MSAPRP scores are sensitive for evaluating disease discrimination and clinical correlates. This study supports differential diagnosis of MSA regardless of different patient populations, PET scanners and imaging protocols.
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