ArticleNeuroImage. Clinical2020
Neural primacy of the dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Limited Efficacy of 3 mA Intensified tDCS of the Right Inferior Frontal Cortex for OCD Treatment: A Randomized, Double-Blind, Sham-Controlled Study.CNS neuroscience & therapeutics · 2026Trial
- Targeting the prefrontal-supplementary motor network in obsessive-compulsive disorder with intensified electrical stimulation in two dosages: a randomized, controlled trial.Translational psychiatry · 2024Trial
- Distinct neural substrates of obsessions and compulsions in adolescent obsessive compulsive disorder.Translational psychiatry · 2026Article
- An evolutionary view on the developing prefrontal cortex connectome and its psychopathological networks: Tract tracing and imaging studies linking two distant anthropoid species.Research square · 2026Article
- Differences in brain functioning between obsessive-compulsive disorder and generalized anxiety disorder: a clinical study using functional near-infrared spectroscopy.Frontiers in psychiatry · 2026Article
- Dysregulated connectivity configuration of triple-network model in obsessive-compulsive disorder.Molecular psychiatry · 2025Article
- Localizing dorsolateral prefrontal cortex for noninvasive brain stimulation in adolescents: A comparison between BeamF3 and 10-20 EEG systems: A cross-sectional study.Indian journal of psychiatry · 2025Article
- Comparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Metaanalysis of Repetitive Transcranial Magnetic Stimulation (rTMS) Efficacy for OCD Treatment: The Impact of Stimulation Parameters, Symptom Subtype and rTMS-Induced Electrical Field.Journal of clinical medicine · 2024Review
- Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis.Frontiers in psychiatry · 2024Review
- Neurological activation during verbal fluency task and resting-state functional connectivity abnormalities in obsessive-compulsive disorder: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2024Article
- Underlying mechanisms of mindfulness meditation: Genomics, circuits, and networks.World journal of psychiatry · 2022Review
- Altered Intrinsic Brain Activity in Patients With Toothache Using the Percent Amplitude of a Fluctuation Method: A Resting-State fMRI Study.Frontiers in neurology · 2022Article
- Psychedelics and Other Psychoplastogens for Treating Mental Illness.Frontiers in psychiatry · 2021Review
- Continuous Theta-Burst Stimulation Over the Right Orbitofrontal Cortex in Treatment-Resistant Obsessive-Compulsive Disorder Treatment: A Randomized Sham-Controlled Trial.International journal of general medicine · 2021Article
- Brain Activation of Patients With Obsessive-Compulsive Disorder During a Mental Rotation Task: A Functional MRI Study.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsolateral prefrontal cortex (DLPFC), a key structure in the executive system, has consistently emerged as a crucial element in the pathophysiology of obsessive-compulsive disorder (OCD). However, the neural primacy of the DLPFC remains elusive in this disorder. We investigated the causal interaction (measured by effective connectivity) between the DLPFC and the remaining brain areas using bivariate Granger causality analysis of resting-state fMRI collected from 88 medication-free OCD patients and 88 matched healthy controls. Additionally, we conducted seed-based functional connectivity (FC) analyses to identify network-level neural functional alterations using the bilateral DLPFC as seeds. OCD patients demonstrated reduced FC between the right DLPFC and right orbitofrontal cortex (OFC), and activity in the right OFC had an inhibitory effect on the right DLPFC. Additionally, we observed alterations in both feedforward and reciprocal influences between the inferior temporal gyrus (ITG) and the DLPFC in patients. Furthermore, activity in the cerebellum had an excitatory influence on the right DLPFC in OCD patients. These findings may help to elucidate the psychopathology of OCD by detailing the directional connectivity between the DLPFC and the rest of the brain, ultimately helping to identify regions that could serve as treatment targets in OCD.
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