SynthesisJournal of clinical epidemiology2021
A systematic review finds Core Outcome Set uptake varies widely across different areas of health.
Synthesis in Journal of clinical epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Real-world effectiveness and safety of difelikefalin for chronic kidney disease-associated pruritus: a systematic review.Renal failure · 2026Pooled it
- COPD maintenance trials use heterogeneous outcomes and measurement instruments: a systematic literature review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Continuity of outcome assessment throughout the lifecycle of surgical research: mapping core outcome domains measured in early phase and late phase studies.BMC surgery · 2025Pooled it
- How do we measure dysarthria after stroke? A systematic review to guide the core outcome set for dysarthria.BMJ open · 2025Pooled it
- Core outcome sets for spinal and associated limb, trunk, abdomen or pelvic pain: A systematic review.PloS one · 2025Pooled it
- Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration.Diabetes care · 2024Pooled it
- Outcomes in intervention research on snakebite envenomation: a systematic review.F1000Research · 2022Pooled it
- In-depth qualitative interviews identified barriers and facilitators that influenced chief investigators' use of core outcome sets in randomised controlled trials.Journal of clinical epidemiology · 2022Trial
- A survey of knowledge, perceptions and use of core outcome sets among clinical trialists.Trials · 2021Trial
- Article
- Development of a Core Outcome Measurement Set for studies of community pharmacist-led medication reviews in older patients with multimorbidity and polypharmacy.International journal of clinical pharmacy · 2026Article
- Consensus on the use of artificial intelligence in the management and measurement of vestibular schwannomas: A protocol for a modified delphi consensus.Neuroradiology · 2026Article
- Outcome measurement instruments for the core outcome sets on genital gender-affirming surgery: the GenderCOS project.EClinicalMedicine · 2026Article
- Challenges in Clinical Research for Nerve Injuries (Nerve SPACE 2025).Journal of hand surgery global online · 2026Article
- Stakeholder perspectives on musculoskeletal pain assessment and management in the UK: a qualitative study.Therapeutic advances in musculoskeletal disease · 2026Article
- Development and Content of Core Outcome Sets in Neonatology-A Scoping Review.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Development of core outcome sets for effectiveness trials focused on infants and children with wasting and nutritional oedema.BMJ global health · 2025Article
- Review
- Article
- Measuring What Matters in Parkinson's Disease Research and Dysphagia: The Need for Core Outcome Sets.Movement disorders : official journal of the Movement Disorder Society · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveThe aim of our review was to bring together studies that had assessed the uptake of core outcome sets (COS) to explore the level of uptake across different COS and areas of health. STUDY DESIGN AND
settingWe examined the citations of 337 COS reports to identify studies that had assessed the uptake of a particular COS in randomized controlled trials (RCTs) or systematic reviews (SRs).
resultsWe identified 24 studies that had assessed uptake in RCTs and two studies that had assessed uptake in SRs. The studies covered a total of 17/337 (5%) COS. Uptake rates reported for RCTs varied from 0% of RCTs (gout) to 82% RCTs (rheumatoid arthritis) measuring the full COS. Studies that assessed uptake of individual core outcomes showed a wide variation in uptake between the outcomes. Suggested barriers to uptake included lack of validated measures, lack of patient and other key stakeholder involvement in COS development, and lack of awareness of the COS.
conclusionsFew studies have been undertaken to assess the uptake of COS in RCTs and SRs. Further studies are needed to assess whether COS have been implemented across a wider range of disease categories and to explore the barriers and facilitators to COS uptake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.