Evidence map›Paper›PMID 32986961›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Fragmented sinoatrial dynamics in the prediction of atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis.

Madalena D Costa, Susan Redline, Elsayed Z Soliman, Ary L Goldberger, Susan R Heckbert

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  4. Association between heart rate fragmentation and kidney function decline in MESA: evidence consistent with parasympathetic degradation.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
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  9. Heart rate fragmentation and brain MRI markers of small vessel disease in MESA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  12. Diagnostic values of different ECG durations in paroxysmal AF diagnosis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Madalena D CostaMargret and H. A. Rey Institute for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Susan RedlineDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-6585-1610
Elsayed Z SolimanEpidemiological Cardiology Research Center, Department of Epidemiology and Prevention and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Ary L GoldbergerMargret and H. A. Rey Institute for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, Washington.
Beth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USUniversity of Washington · USWake Forest University · US

Funding

ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPSR01HL098433 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2010 to 2015
$8.2M
National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4M
Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2M
Research Resource for Complex Physiologic SignalsR01EB030362 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GOLDBERGER, ARY LOUIS · 2020 to 2025
$5.8M
Research Resource for Complex Physiologic SignalsR01GM104987 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GOLDBERGER, ARY LOUIS, MARK, ROGER GREENWOOD · 2012 to 2019
$5.8M
Heart Rate Fragmentation: New Biomarker of Atrial Fibrillation RiskR01HL144510 · NHLBI · UNIVERSITY OF WASHINGTON · PI COSTA, MADALENA D, HECKBERT, SUSAN R · 2019 to 2022
$2.4M
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01HL144510HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R35HL135818HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB030362HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM104987NHLBI NIH HHS R01 HL098433NHLBI NIH HHS R01 HL127659NHLBI NIH HHS R01 HL144510NHLBI NIH HHS R24 HL114473NHLBI NIH HHS R35 HL135818NIBIB NIH HHS R01 EB030362
6 · The paper itself

Abstract

Heart rate fragmentation (HRF), a marker of abnormal sinoatrial dynamics, was shown to be associated with incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Here, we test the hypothesis that HRF is also associated with incident atrial fibrillation (AF) in the MESA cohort of participants who underwent in-home polysomnography (PSG) and in two high-risk subgroups: those ≥70 yr taking antihypertensive medication and those with serum concentrations of NH

Indexed as

ElectrocardiographyHeart RateAction PotentialsAgedAged, 80 and overAge FactorsAntihypertensive AgentsAtrial FibrillationAutonomic Nervous SystemBiomarkersBlood PressureFemaleHeart Disease Risk FactorsHumansHypertensionIncidenceAntihypertensive AgentsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)atrial fibrillationautonomic nervous systemheart rate fragmentationheart rate variabilitysinus node

Identifiers

PMID32986961
PMCPMC7847074
OpenAlexW3091393516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.