ReviewJournal of clinical hypertension (Greenwich, Conn.)2020
Wide pulse pressure: A clinical review.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 75 citations in OpenAlex.
- Impact of pulse pressure variability evaluated by visit-to-visit on heart failure events in patients with hypertension: insights from the SPRINT trial.European journal of medical research · 2024Trial
- Blood pressure parameters and the risk of chronic limb-threatening ischemia: The Singapore Chinese Health Study.Journal of vascular surgery · 2026Article
- Evaluation of Pulse Pressure as a Hemodynamic Marker of Cardiac Disease in Dogs and Horses Undergoing Pre-Anesthetic Assessment.Animals : an open access journal from MDPI · 2026Article
- Self-powered in-stent restenosis diagnosis via magnetoelastic stents.Nature cardiovascular research · 2026Article
- Low admission pulse pressure and increased in-hospital mortality in patients with heart failure.Frontiers in cardiovascular medicine · 2026Article
- Blood pressure indices for predicting incident cardiovascular disease: A 13-year follow-up study in Japanese population.American journal of preventive cardiology · 2025Article
- Hyperdynamic circulation distinguishes predominantly diastolic hypertension from predominantly systolic hypertension.Journal of human hypertension · 2025Article
- Pulse Pressure and Adverse Maternal and Perinatal Outcomes in Patients With Mild Chronic Hypertension During Pregnancy.O&G open · 2025Article
- Disentangling unobserved heterogeneity: Novel application of a statistical method to evaluate a multilevel healthcare intervention for hispanic individuals living on the United States-Mexico border with comorbid diabetes and hypertension.Preventive medicine reports · 2025Article
- Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan.Annals of clinical and translational neurology · 2025Article
- Impact of personalized accurate intensity exercise on radial artery pulse wave in patients with multi-chronic diseases: a holistic functional assessment approach.Journal of thoracic disease · 2025Article
- Association Between Pulse Pressure and the Risk of Death Events - Beijing Municipality, China, 2010-2021.China CDC weekly · 2025Article
- Multivariate linear regression to predict association of non-invasive arterial stiffness with cardiovascular events.ESC heart failure · 2025Article
- Advanced ECG Analysis to Evaluate Multimodal Exercise Effects on Cardiovascular Health.Medicina (Kaunas, Lithuania) · 2025Article
- Education differences in blood pressure trajectories by sex through midlife: Findings from the National Health and Nutrition Examination Survey, 1999-2018.Blood pressure monitoring · 2025Article
- Control of Pulse Pressure and Factors Affecting it among the Geriatric Population Suffering from Hypertension within the Community.Reviews in cardiovascular medicine · 2025Article
- Blunted cardiovascular responses in individuals with type 2 diabetes and hypertension during cold and heat exposure.Frontiers in physiology · 2025Article
- A Mechanical-Electrochemical Dual-Model E-Skin for the Monitoring of Cardiovascular Healthcare.Biosensors · 2024Article
- Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function: The Strong Heart Study.JACC. Advances · 2024Article
- Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms.Translational stroke research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulse pressure naturally increases over time as individuals' age due to arteriosclerosis and diffuse vascular stiffening. However, the differential for widened pulse pressure is broad and includes causes of hyperdynamic circulation and high-output heart failure, such as aortic regurgitation and hyperthyroidism. In the absence of an underlying cause, wide pulse pressure is a sign of deteriorating cardiovascular health and carries increased risk for mortality, disease progression, and adverse clinical outcomes in chronic diseases including cardiovascular disease and chronic kidney disease. Current emphasis of antihypertensive treatment on systolic and diastolic blood pressure does not always address pulse pressure, thus subjecting many patients to an independent risk factor for poor outcomes. Pulse pressure control is more successfully achieved with thiazide diuretics and long-acting nitrates when compared to other antihypertensive agents, but further research is needed to quantify the additional benefits of pulse pressure control over conventional blood pressure therapy. This case review provides an overview of the pathogenesis, pathologic causes, and treatment of widened pulse pressure and evaluates current evidence for pulse pressure as a predictor of clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.