Evidence map›Paper›PMID 32986852›Full record

ArticleImmunology2021

A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain.

Alessandro Didonna, Vincent Damotte, Hengameh Shams, Atsuko Matsunaga, Stacy J Caillier, Ravi Dandekar, Maneesh K Misra, Mohammad R K Mofrad, Jorge R Oksenberg, Jill A Hollenbach

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Alessandro DidonnaDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7510-9658
Vincent DamotteDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Hengameh ShamsDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Atsuko MatsunagaDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Stacy J CaillierDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Ravi DandekarDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Maneesh K MisraDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Mohammad R K MofradMolecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA, USA.
Jorge R OksenbergDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Jill A HollenbachDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6572-7962
University of California, San Francisco · USLawrence Berkeley National Laboratory · US

Funding

P0531582 Oksenberg/Hollenbach R01NS102153 SupplementR01NS102153 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON, OKSENBERG, JORGE R. · 2017 to 2021
$3.6M
NINDS NIH HHS R01 NS102153
6 · The paper itself

Abstract

Class II human leucocyte antigen (HLA) proteins are involved in the immune response by presenting pathogen-derived peptides to CD4

Indexed as

AdultAgedAmino AcidsAntigen-Presenting CellsBinding SitesCell LineCell Line, TumorCell MembraneEndoplasmic ReticulumFemaleHEK293 CellsHeLa CellsHistocompatibility Antigens Class IIHLA-DR alpha-ChainsHumansLeukocytes, MononuclearAmino AcidsHistocompatibility Antigens Class IIHLA-DR alpha-ChainsPeptidesProtein Isoformsantigen presentationhuman leucocyte antigenimmune responseprotein folding

Identifiers

PMID32986852
PMCPMC7808164
OpenAlexW3089900066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.