ArticleGenome biology and evolution2020
Evolution of a Record-Setting AT-Rich Genome: Indel Mutation, Recombination, and Substitution Bias.
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
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- Insights into the Phylogeny and Enigmatic Mitochondrial Biology of Eustigmatophyte Algae From Over 50 Newly Sequenced Organellar Genomes.Genome biology and evolution · 2026Article
- Charting the landscape of organellar genome evolution in eustigmatophyte algae.bioRxiv : the preprint server for biology · 2026Article
- Genomic and phenotypic characterization of a human gutFuture microbiology · 2026Article
- From Rigid Order to Radical Variation: Mitogenome Evolution in the Main Lineages of a Lesser-Known Animal Phylum (Gastrotricha).Genome biology and evolution · 2026Article
- A record-setting mitogenome in the holoparasitic plant Balanophora yakushimensis accompanied by exceptional loss of organellar DNA repair and recombination genes.BMC biology · 2025Article
- Mitochondrial Genome Diversity across the Subphylum Saccharomycotina.bioRxiv : the preprint server for biology · 2023Article
- Mitochondrial genome diversity across the subphylum Saccharomycotina.Frontiers in microbiology · 2023Article
- Mitogenomics and mitochondrial gene phylogeny decipher the evolution of Saccharomycotina yeasts.Genome biology and evolution · 2022Article
- The complete mitochondrial genomes of Paradiplozoon yarkandense and Paradiplozoon homoion confirm that Diplozoidae evolve at an elevated rate.Parasites & vectors · 2022Article
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- Complete mitochondrial genome of giant cricketMitochondrial DNA. Part B, Resources · 2022Article
- From Genome Variation to Molecular Mechanisms: What we Have Learned From Yeast Mitochondrial Genomes?Frontiers in microbiology · 2022Review
- The Complete Mitochondrial Genome of Lepidotrigona flavibasis (Hymenoptera: Meliponini) and High Gene Rearrangement in Lepidotrigona Mitogenomes.Journal of insect science (Online) · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide nucleotide composition varies widely among species. Despite extensive research, the source of genome-wide nucleotide composition diversity remains elusive. Yeast mitochondrial genomes (mitogenomes) are highly A + T rich, and they provide a unique opportunity to study the evolution of AT-biased landscape. In this study, we sequenced ten complete mitogenomes of the Saccharomycodes ludwigii yeast with 8% G + C content, the lowest genome-wide %(G + C) in all published genomes to date. The S. ludwigii mitogenomes have high densities of short tandem repeats but severely underrepresented mononucleotide repeats. Comparative population genomics of these record-setting A + T-rich genomes shows dynamic indel mutations and strong mutation bias toward A/T. Indel mutations play a greater role in genomic variation among very closely related strains than nucleotide substitutions. Indels have resulted in presence-absence polymorphism of tRNAArg (ACG) among S. ludwigii mitogenomes. Interestingly, these mitogenomes have undergone recombination, a genetic process that can increase G + C content by GC-biased gene conversion. Finally, the expected equilibrium G + C content under mutation pressure alone is higher than observed G + C content, suggesting existence of mechanisms other than AT-biased mutation operating to increase A/T. Together, our findings shed new lights on mechanisms driving extremely AT-rich genomes.
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