Evidence map›Paper›PMID 32986769›Full record

ArticlePloS one2020

Interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and between genes and physical activities on physical performance in community-dwelling elders.

Tsai-Chung Li, Ching-Wei Wu, Chia-Ing Li, Fang-Yang Wu, Li-Na Liao, Chiu-Shong Liu, Chih-Hsueh Lin, Mu-Cyun Wang, Chuan-Wei Yang, Cheng-Chieh Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Regulatory Role of the AKT1/AMPK Pathway in Oxidative Stress of Lens Epithelial Cells in Cataract Patients].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
  2. Mutations in theInternational journal of molecular sciences · 2024
    Article
  3. Genome Editing to Abrogate Muscle Atrophy.Advances in experimental medicine and biology · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tsai-Chung LiDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.ORCID 0000-0002-3346-7462
Ching-Wei WuDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Chia-Ing LiSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Fang-Yang WuDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Li-Na LiaoDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Chiu-Shong LiuSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Chih-Hsueh LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Mu-Cyun WangSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Chuan-Wei YangDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Cheng-Chieh LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the interactions among IGF-1, AKT2, FOXO1, and FOXO3 variations and the interactions of gene and physical activity on handgrip strength, arm muscle mass-adjusted handgrip (armGrip), gait speed (GS), timed up and go (TUG), and leg press strength (LPS). Nine single nucleotide polymorphisms (SNPs) containing three IGF-1 SNPs (rs6214, rs5742692, and rs35767), two AKT2 SNPs (rs892119 and rs35817154), two FOXO1 SNPs (rs17446593 and rs10507486), and two FOXO3 SNPs (rs9480865 and rs2153960) were genotyped in 472 unrelated elders with a mean age of 73.8 years. We observed significant interactions of IGF-1 SNP rs6214 and rs35767 with regular physical activity on TUG and GS; and AKT2 SNP rs892119 and FOXO3 SNP rs9480865 with regular physical activity on armGrip. Genotype GG of IGF-1 rs6214 and rs35767 in individuals without regular physical activity had poor performance in TUG and GS, as well as GG of AKT2 rs892119 decreased armGrip in individuals without regular physical activity. After FDR adjustment, no significant gene-gene interactions were found. A sedentary lifestyle may increase the risk of impairing physical performance and regular physical activity is a remedy for sarcopenia, even a little regular physical activity can overcome carrying some risk alleles in this pathway.

Indexed as

AgedAllelesExerciseFemaleForkhead Box Protein O1Forkhead Box Protein O3Gene FrequencyGenotypeHand StrengthHumansInsulin-Like Growth Factor IMalePhysical Functional PerformancePolymorphism, Single NucleotideProto-Oncogene Proteins c-aktSarcopeniaAKT2 protein, humanForkhead Box Protein O1Forkhead Box Protein O3FOXO1 protein, humanFOXO3 protein, humanIGF1 protein, humanInsulin-Like Growth Factor IProto-Oncogene Proteins c-akt

Identifiers

PMID32986769
PMCPMC7521683
OpenAlexW3090595554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.