Evidence map›Paper›PMID 32986582›Full record

ArticleInternational journal of spine surgery2020

Intradiscal Delivery of Anabolic Growth Factors and a Metalloproteinase Inhibitor in a Rabbit Acute Lumbar Disc Injury Model.

Sapan D Gandhi, Tristan Maerz, Sean Mitchell, Casey Bachison, Daniel K Park, Jeffrey S Fischgrund, Kevin C Baker

Open access · diamondAbstract read
In one paragraph

Article in International journal of spine surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. [Research progress of hydrogel-based growth factors for treatment of intervertebral disc degeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
  2. Review
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  6. ISSLS Prize in Bioengineering Science 2022: low rate cyclic loading as a therapeutic strategy for intervertebral disc regeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sapan D GandhiDepartment of Orthopaedic Surgery, Beaumont Health System, Royal Oak, Michigan.
Tristan MaerzDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan.
Sean MitchellDepartment of Orthopaedic Surgery, Beaumont Health System, Royal Oak, Michigan.
Casey BachisonDepartment of Orthopaedic Surgery, Beaumont Health System, Royal Oak, Michigan.
Daniel K ParkDepartment of Orthopaedic Surgery, Beaumont Health System, Royal Oak, Michigan.
Jeffrey S FischgrundDepartment of Orthopaedic Surgery, Beaumont Health System, Royal Oak, Michigan.
Kevin C BakerDepartment of Orthopaedic Surgery, Beaumont Health System, Royal Oak, Michigan.
Beaumont Health · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of our study was to examine the effect of controlled delivery of TGF-β

methodsAfter conducting an in vitro analysis of the chondrogenic capacity of the biomolecule cocktail use (ie, TGF-β

resultsIn the in vitro analysis, cells treated with experimental media containing TGF-β

conclusionsA combination of chitosan, TGF-β

Indexed as

bmp-4; disc injurydisc degenerationdisc regenerationmetalloproteinase inhibitorTGF-beta

Identifiers

PMID32986582
PMCPMC7478067
OpenAlexW3211605312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.