Evidence map›Paper›PMID 32986541›Full record

ArticleIEEE transactions on bio-medical engineering2021

DcardNet: Diabetic Retinopathy Classification at Multiple Levels Based on Structural and Angiographic Optical Coherence Tomography.

Pengxiao Zang, Liqin Gao, Tristan T Hormel, Jie Wang, Qisheng You, Thomas S Hwang, Yali Jia

Abstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

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0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  7. Advances in OCT Angiography.Translational vision science & technology · 2025
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Pengxiao Zang
Liqin Gao
Tristan T Hormel
Jie Wang
Qisheng You
Thomas S Hwang
Yali Jia

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
OCTA Precursors of Vision-Threatening Complications of Diabetic RetinopathyR01EY035410 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Thomas Hwang, Yali Jia · 2023 to 2026
$2.5M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
Wide-field and projection-resolved optical coherence tomography angiography in diabetic retinopathyR01EY027833 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HWANG, THOMAS, JIA, YALI · 2017 to 2020
$1.8M
Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucomaR01EY031394 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JIA, YALI, MORRISON, JOHN C · 2020 to 2022
$1.6M
Functional Optical Coherence Tomography-derived Biomarkers for Diabetic RetinopathyDP3DK104397 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JIA, YALI, WILSON, DAVID J · 2014 to 2014
$1.0M
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY027833NEI NIH HHS R01 EY031394NEI NIH HHS R01 EY035410NEI NIH HHS T32 EY023211NIDDK NIH HHS DP3 DK104397
6 · The paper itself

Abstract

objectiveOptical coherence tomography (OCT) and its angiography (OCTA) have several advantages for the early detection and diagnosis of diabetic retinopathy (DR). However, automated, complete DR classification frameworks based on both OCT and OCTA data have not been proposed. In this study, a convolutional neural network (CNN) based method is proposed to fulfill a DR classification framework using en face OCT and OCTA.

methodsA densely and continuously connected neural network with adaptive rate dropout (DcardNet) is designed for the DR classification. In addition, adaptive label smoothing was proposed and used to suppress overfitting. Three separate classification levels are generated for each case based on the International Clinical Diabetic Retinopathy scale. At the highest level the network classifies scans as referable or non-referable for DR. The second level classifies the eye as non-DR, non-proliferative DR (NPDR), or proliferative DR (PDR). The last level classifies the case as no DR, mild and moderate NPDR, severe NPDR, and PDR.

resultsWe used 10-fold cross-validation with 10% of the data to assess the network's performance. The overall classification accuracies of the three levels were 95.7%, 85.0%, and 71.0% respectively. CONCLUSION/SIGNIFICANCE: A reliable, sensitive and specific automated classification framework for referral to an ophthalmologist can be a key technology for reducing vision loss related to DR.

Indexed as

Diabetes MellitusDiabetic RetinopathyAngiographyEarly DiagnosisHumansNeural Networks, ComputerTomography, Optical Coherence

Identifiers

PMID32986541
PMCPMC8191487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.