Evidence map›Paper›PMID 32986345›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

CD133 Role in Oral Carcinogenesis.

Ealber Carvalho Macedo Luna, Thâmara Manoela Marinho Bezerra, Paulo Goberlânio De Barros Silva, Roberta Barroso Cavalcante, Fábio Wildson Gurgel Costa, Ana Paula Negreiros Nunes Alves, Filipe Nobre Chaves, Karuza Maria Alves Pereira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ealber Carvalho Macedo LunaDepartment of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.
Thâmara Manoela Marinho BezerraDepartment of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.ORCID 0000-0002-2435-7106
Paulo Goberlânio De Barros SilvaDepartment of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.ORCID 0000-0002-1513-9027
Roberta Barroso CavalcanteDepartment of Oral Pathology, Faculty of Dentistry, Universidade de Fortaleza, Fortaleza, Ceara, Brazil.
Fábio Wildson Gurgel CostaDepartment of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.ORCID 0000-0002-3262-3347
Ana Paula Negreiros Nunes AlvesDepartment of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.
Filipe Nobre ChavesSchool of Dentistry, Federal University of Ceará Campus Sobral, Sobral, Brazil.ORCID 0000-0001-6345-8156
Karuza Maria Alves PereiraDepartament of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Brazil.ORCID 0000-0002-2880-6466
Universidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveto investigate CD133 immunoexpression, cancer stem cells marker, in oral epithelial dysplasias (OEDs) and oral squamous cells carcinomas (OSCCs) and understandits possible involvement in the malignant transformation process of these lesions and to better elucidate their biological behavior. MATERIAL AND

methodsTissue samples of 15 cases of OSCCs and 15 OEDs were subjected to CD133 antibody immunohistochemistry reactions. The analysis used quantitative parameters (number of immunostained cells regardless of immunostaining sublocations).

resultsAll samples of OSCCs and OEDs showed positive immunostaining, with no significant difference between these groups (p = 0.283). We did not observe statistical difference between the degree of dysplasia and the amount of CD133+ cells (p = 0.899). CD133 immunoexpression showed no association with the OEDs and OSCCs sites. It was observed that nuclear and cytoplasmic immunostaining was more evident with the progression of the malignant process.

conclusionIt is suggested that the CD133 cellular localization together with the histopathological criteria of OEDs classification can contribute to provide more concrete indications about the oral carcinogenesis process.

Indexed as

AC133 AntigenAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Squamous CellFemaleFocal Epithelial HyperplasiaFollow-Up StudiesHumansMaleMiddle AgedMouth NeoplasmsPrecancerous ConditionsPrognosisAC133 AntigenBiomarkers, TumorPROM1 protein, humanCD133oral carcinogenesisoral squamous cells carcinomapremalignant lesionsstem cells

Identifiers

PMID32986345
PMCPMC7779460
OpenAlexW3089878741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.