ArticleJournal of clinical laboratory analysis2020
Comprehensive laboratory reference intervals for routine biochemical markers and pro-oxidant-antioxidant balance (PAB) in male adults.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Serum vitamin D and lipid profile differences between breastfed and Formula-fed infants.Journal of health, population, and nutrition · 2025Article
- Investigation of Serum Nitric Oxide, Zinc, Copper, and C-Reactive Protein Levels in Acute Hepatitis B Patients.Biological trace element research · 2025Article
- Association Between Socio-Economic Status (SES) and the Traditional Risk Factors of Cardiovascular Diseases (CVD): A Cross-Sectional MASHAD Cohort Study Results.Health science reports · 2025Article
- The associations of oxidative stress and inflammatory markers with obesity in Iranian population: MASHAD cohort study.BMC endocrine disorders · 2024Article
- Age-specific reference intervals for liver function tests in healthy neonates, infants, and young children in Iran.Journal of clinical laboratory analysis · 2023Article
- Do We Need Pakistan-Specific Reference Ranges in Laboratory Medicine?Journal of laboratory physicians · 2023Article
- Comprehensive laboratory reference intervals for routine biochemical markers and pro-oxidant-antioxidant balance (PAB) in male adults.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
18 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundReference values of biochemical markers are influenced by various parameters including age, sex, region, and lifestyle. Hence, we aimed to determine age- and BMI-specific reference intervals (RIs) for important clinical biomarkers in a healthy adult male population from northeastern Iran. This is also the first study to investigate reference values for pro-oxidant-antioxidant balance (PAB).
methodsSeven hundred and twenty (720) healthy men, aged 20-60 years, were recruited from Sarakhs in the northeast region of Iran. Reference values for lipid profiles (total cholesterol, triglyceride, HDL-C and LDL-C), fasting blood glucose, inflammatory factors (hs-CRP and PAB), minerals (zinc and copper), uric acid, and blood pressure were measured and statistically analyzed to establish accurate age- and BMI-specific RIs in alignment with CLSI Ep28-A3 guidelines.
resultsRIs for lipid profiles, inflammatory factors, minerals, and uric acid required no age partitioning with the exception of fasting blood glucose and blood pressure, which demonstrated significantly higher values in subjects aged 50 years and older. Among these biomarkers, only uric acid, blood pressure, and triglycerides demonstrated statistically significant increases in reference value concentrations with increasing BMI.
conclusionIn this study, age- and BMI-specific RIs for several biochemical markers were determined in healthy adult Iranian men. Partitioning by age and BMI was only required for a few analytes with most demonstrating no statistically significant changes with these covariates. These data can be useful to monitor various diseases in male adults with varying BMI in this region and others.
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