ArticleeLife2020
Testicular hormones mediate robust sex differences in impulsive choice in rats.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Stress-coping behavior during predator odor exposure is associated with differences in decision making.Addiction neuroscience · 2026Article
- Combined maternal separation and limited bedding-nesting increase goal tracking, delay discounting, and impulsive action, and moderate sign-tracking-perseverance associations in male rats.BMC neuroscience · 2026Article
- Stress-coping behavior during predator odor exposure is associated with differences in decision making.bioRxiv : the preprint server for biology · 2026Article
- Social isolation increases impulsive choice with minor changes on metabolic function in middle-aged rats.Physiological reports · 2025Article
- Sex mechanisms as nonbinary influences on cognitive diversity.Hormones and behavior · 2024Review
- Giftedness and atypical sexual differentiation: enhanced perceptual functioning through estrogen deficiency instead of androgen excess.Frontiers in endocrinology · 2024Review
- Effects of reproductive experience on cost-benefit decision making in female rats.Frontiers in behavioral neuroscience · 2024Article
- Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.BMC neuroscience · 2023Review
- Behavioral mechanisms of oxycodone's effects in female and male rats: Reinforcement delay and impulsive choice.Experimental and clinical psychopharmacology · 2023Article
- Reward maximization assessed using a sequential patch depletion task in a large sample of heterogeneous stock rats.Scientific reports · 2023Article
- Cognitive mechanisms underlying decision making involving risk of explicit punishment in male and female rats.Cognitive, affective & behavioral neuroscience · 2023Article
- Effects of the estrous cycle on impulsive choice and interval timing in female rats.Hormones and behavior · 2023Article
- Reward Maximization Assessed Using a Sequential Patch Depletion Task in a Large Sample of Heterogeneous Stock Rats.Research square · 2023Article
- Sex differences in patch-leaving foraging decisions in rats.Oxford open neuroscience · 2023Article
- Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise.Behavioural brain research · 2022Article
- Regulation of sex differences in risk-based decision making by gonadal hormones: Insights from rodent models.Behavioural processes · 2022Review
- GABANeuropharmacology · 2022Article
- Effect of Sex and Reproductive Status on Inhibitory Control and Social Cognition in the Domestic Dog (Animals : an open access journal from MDPI · 2021Article
- Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood.Journal of psychopharmacology (Oxford, England) · 2021Article
- Mental Resilience and Coping With Stress: A Comprehensive, Multi-level Model of Cognitive Processing, Decision Making, and Behavior.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Impairments in choosing optimally between immediate and delayed rewards are associated with numerous psychiatric disorders. Such 'intertemporal' choice is influenced by genetic and experiential factors; however, the contributions of biological sex are understudied and data to date are largely inconclusive. Rats were used to determine how sex and gonadal hormones influence choices between small, immediate and large, delayed rewards. Females showed markedly greater preference than males for small, immediate over large, delayed rewards (greater impulsive choice). This difference was neither due to differences in food motivation or reward magnitude perception, nor was it affected by estrous cycle. Ovariectomies did not affect choice in females, whereas orchiectomies increased impulsive choice in males. These data show that male rats exhibit less impulsive choice than females and that this difference is at least partly maintained by testicular hormones. These differences in impulsive choice could be linked to gender differences across multiple neuropsychiatric conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.