ReviewJournal of cachexia, sarcopenia and muscle2020
Diverging metabolic programmes and behaviours during states of starvation, protein malnutrition, and cachexia.
Review in Journal of cachexia, sarcopenia and muscle, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Trial
- Nutritional Status-Based Model for Predicting Low-Lactate Shock: A Retrospective Cohort Study.Shock (Augusta, Ga.) · 2026Article
- Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026Article
- Disease-specific growth charts capture characteristic growth patterns in children with PMM2 - CDG.Molecular genetics and metabolism · 2026Article
- Lower insulin resistance in Chinese patients with severe major depressive disorder: associations with the inflammatory response.BMC psychiatry · 2026Article
- Development and validation of a tool for detecting misinformation risk in diet, nutrition, and health content (Diet-MisRAT).Scientific reports · 2026Article
- Positive and negative energy surpluses in persons with chronic spinal cord injury.The British journal of nutrition · 2025Article
- The Role of Previous History of Muscle Wasting in Burn Outcomes-A Burn Care Quality Platform Study.European burn journal · 2025Article
- The Effects of Iterative Freeze-Thaw Cycles on the Structure, Functionality, and Digestibility ofFoods (Basel, Switzerland) · 2025Article
- Proteins from Edible Mushrooms: Nutritional Role and Contribution to Well-Being.Foods (Basel, Switzerland) · 2025Review
- Human adaptation response to obesity.International journal of obesity (2005) · 2025Review
- Glucose, glutamine, lactic acid and α‑ketoglutarate restore metabolic disturbances and atrophic changes in energy‑deprived muscle cells.Molecular medicine reports · 2025Article
- Effects of Long-Term Fasting on Gut Microbiota, Serum Metabolome, and Their Association in Male Adults.Nutrients · 2024Article
- Family Members' Explanatory Models of Cancer Anorexia-Cachexia.Healthcare (Basel, Switzerland) · 2024Article
- Integrative Approach of Treating Early Undernutrition with an Enriched Black Corn Chip, Study on a Murine Model.Nutrients · 2024Article
- Immunoregulation in cancer-associated cachexia.Journal of advanced research · 2024Review
- Unveiling Skin Manifestations: Exploring Cutaneous Signs of Malnutrition in Eating Disorders.Cureus · 2023Review
- Malnutrition Patterns in Children with Chronic Kidney Disease.Life (Basel, Switzerland) · 2023Review
- Similarities and differences regarding acute anorexia nervosa and semi-starvation: does behavioral thermoregulation play a central role?Frontiers in behavioral neuroscience · 2023Article
- Nanoparticle-Based Follistatin Messenger RNA Therapy for Reprogramming Metastatic Ovarian Cancer and Ameliorating Cancer-Associated Cachexia.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundOur evolutionary history is defined, in part, by our ability to survive times of nutrient scarcity. The outcomes of the metabolic and behavioural adaptations during starvation are highly efficient macronutrient allocation, minimization of energy expenditure, and maximized odds of finding food. However, in different contexts, caloric deprivation is met with vastly different physiologic and behavioural responses, which challenge the primacy of energy homeostasis.
methodsWe conducted a literature review of scientific studies in humans, laboratory animals, and non-laboratory animals that evaluated the physiologic, metabolic, and behavioural responses to fasting, starvation, protein-deficient or essential amino acid-deficient diets, and cachexia. Studies that investigated the changes in ingestive behaviour, locomotor activity, resting metabolic rate, and tissue catabolism were selected as the focus of discussion.
resultsWhereas starvation responses prioritize energy balance, both protein malnutrition and cachexia present existential threats that induce unique adaptive programmes, which can exacerbate the caloric insufficiency of undernutrition. We compare and contrast the behavioural and metabolic responses and elucidate the mechanistic pathways that drive state-dependent alterations in energy seeking and partitioning.
conclusionsThe evolution of energetically inefficient metabolic and behavioural responses to protein malnutrition and cachexia reveal a hierarchy of metabolic priorities governed by discrete regulatory networks.
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Registered trials
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