ArticleAngewandte Chemie (International ed. in English)2021
A Gold Nanoparticle Nanonuclease Relying on a Zn(II) Mononuclear Complex.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Nanozymes for ferroptosis-based cancer theranostics.Bioactive materials · 2026Review
- Assessing Hydrolytic Activity of Surfactant-Based Nanozymes: Methodological and Kinetic Considerations.Nanomaterials (Basel, Switzerland) · 2026Review
- Review
- Cell-free DNA in sepsis: from molecular insights to clinical management.Military Medical Research · 2025Review
- Efficient Cleavage of pUC19 DNA by Tetraaminonaphthols.ChemistryOpen · 2025Article
- Stabilized and Controlled Release of Radicals within Copper Formate-Based Nanozymes for Biosensing.ACS applied materials & interfaces · 2023Article
- Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay.Materials today. Bio · 2023Review
- NanoModeler CG: A Tool for Modeling and Engineering Functional Nanoparticles at a Coarse-Grained Resolution.Journal of chemical theory and computation · 2023Article
- Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy.Coordination chemistry reviews · 2022Review
- Regulation Mechanism of ssDNA Aptamer in Nanozymes and Application of Nanozyme-Based Aptasensors in Food Safety.Foods (Basel, Switzerland) · 2022Review
- On the Metal-Aided Catalytic Mechanism for Phosphodiester Bond Cleavage Performed by Nanozymes.ACS catalysis · 2021Article
- Molecular Recognition by Gold Nanoparticle-Based Receptors as Defined through Surface Morphology and Pockets Fingerprint.The journal of physical chemistry letters · 2021Article
- The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- A Gold Nanoparticle Nanonuclease Relying on a Zn(II) Mononuclear Complex.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Similarly to enzymes, functionalized gold nanoparticles efficiently catalyze chemical reactions, hence the term nanozymes. Herein, we present our results showing how surface-passivated gold nanoparticles behave as synthetic nanonucleases, able to cleave pBR322 plasmid DNA with the highest efficiency reported so far for catalysts based on a single metal ion mechanism. Experimental and computational data indicate that we have been successful in creating a catalytic site precisely mimicking that suggested for natural metallonucleases relying on a single metal ion for their activity. It comprises one Zn(II) ion to which a phosphate diester of DNA is coordinated. Importantly, as in nucleic acids-processing enzymes, a positively charged arginine plays a key role by assisting with transition state stabilization and by reducing the pK
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.