Evidence map›Paper›PMID 32985578›Full record

ArticleScientific reports2020

Interaction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection.

Andrea Fulgione, Marina Papaianni, Paola Cuomo, Debora Paris, Marco Romano, Concetta Tuccillo, Letizia Palomba, Chiara Medaglia, Massimiliano De Seta, Nicolino Esposito and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Metabolic reprogramming inFrontiers in cellular and infection microbiology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Caulerpin MitigatesInternational journal of molecular sciences · 2021
    Article
  8. Review
  9. Journal of gastrointestinal oncology · 2021
    Article
  10. Genetics of Host Protection againstInternational journal of molecular sciences · 2021
    Review
  11. TIRAP in the Mechanism of Inflammation.Frontiers in immunology · 2021
    Review
  12. An In Vitro Model to Investigate the Role ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Andrea Fulgione *Department of Agriculture Sciences, University of Naples "Federico II", Via Università, 100, 80055, Portici, Naples, Italy.
Marina Papaianni *Department of Agriculture Sciences, University of Naples "Federico II", Via Università, 100, 80055, Portici, Naples, Italy.
Paola CuomoDepartment of Agriculture Sciences, University of Naples "Federico II", Via Università, 100, 80055, Portici, Naples, Italy.
Debora ParisInstitute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei, 34, 80078, Pozzuoli, Naples, Italy.
Marco RomanoHepatogastroenterology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", via Pansini, 5, 80131, Naples, Italy.
Concetta TuccilloHepatogastroenterology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", via Pansini, 5, 80131, Naples, Italy.
Letizia PalombaDepartment of Biomolecular Sciences, University of Urbino "Carlo Bo", Via Santa Chiara, 27, 61029, Urbino, Italy.
Chiara MedagliaDepartment of Microbiology and Molecular Medicine, University of Geneva Medical School, Rue du Général-Dufour, 24, 1211, Genève 4, Switzerland.
Massimiliano De SetaFondazione Evangelica Betania, Via Argine, 604, 80147, Naples, Italy.
Nicolino EspositoFondazione Evangelica Betania, Via Argine, 604, 80147, Naples, Italy.
Andrea MottaInstitute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei, 34, 80078, Pozzuoli, Naples, Italy.
Antonio IannelliUniversité Côte D'Azur, Campus Valrose, Batiment L, Avenue de Valrose, 28, 06108, Nice CEDEX 2, France.
Domenico IannelliDepartment of Agriculture Sciences, University of Naples "Federico II", Via Università, 100, 80055, Portici, Naples, Italy. domenico.iannelli1935@gmail.com.
Rosanna Capparelli *Department of Agriculture Sciences, University of Naples "Federico II", Via Università, 100, 80055, Portici, Naples, Italy.
University of Naples Federico II · ITNational Research Council · ITUniversity of Campania "Luigi Vanvitelli" · ITInstitut de Biologie Valrose · FRUniversity of Geneva · CHUniversity of Urbino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Toll-interleukin 1 receptor superfamily includes the genes interleukin 1 receptor-like 1 (IL1RL1), Toll like receptors (TLRs), myeloid differentiation primary-response 88 (MyD88), and MyD88 adaptor-like (TIRAP). This study describes the interaction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection. Cases and controls were genotyped at the polymorphic sites MyD88 rs6853, TIRAP rs8177374 and IL1RL1 rs11123923. The results show that specific combinations of IL1RL1-TIRAP (AA-CT; P: 2,8 × 10

Indexed as

Helicobacter pyloriDisease ResistanceHelicobacter InfectionsHumansInterleukin-1 Receptor-Like 1 ProteinMagnetic Resonance SpectroscopyMembrane GlycoproteinsMyeloid Differentiation Factor 88Real-Time Polymerase Chain ReactionReceptors, Interleukin-1IL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinMembrane GlycoproteinsMYD88 protein, humanMyeloid Differentiation Factor 88Receptors, Interleukin-1TIRAP protein, human

Identifiers

PMID32985578
PMCPMC7522988
OpenAlexW3089074767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.