ArticleScientific reports2020
Genomic and experimental data provide new insights into luciferin biosynthesis and bioluminescence evolution in fireflies.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 34 citations in OpenAlex.
- Panunoids A - D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis.Natural products and bioprospecting · 2026Article
- A practical, biomimetic, one-pot synthesis of firefly luciferin.Scientific reports · 2024Article
- The chromosome-level genome assembly of the giant dobsonfly Acanthacorydalis orientalis (McLachlan, 1899).Scientific data · 2024Article
- Cloning and characterization of luciferase from an Asian firefly Pygoluciola qingyu and its comparison with other beetle luciferases.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Genome assembly of Genji firefly (Nipponoluciola cruciata) reveals novel luciferase-like luminescent proteins without peroxisome targeting signal.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Key homeobox transcription factors regulate the development of the firefly's adult light organ and bioluminescence.Nature communications · 2024Article
- Article
- Multiple Origins of Bioluminescence in Beetles and Evolution of Luciferase Function.Molecular biology and evolution · 2024Article
- Long-Read Genome Sequencing ofZoological studies · 2023Article
- Biosensing firefly luciferin synthesis in bacteria reveals a cysteine-dependent quinone detoxification route in Coleoptera.Scientific reports · 2022Article
- Article
- Luminescent characteristics and mitochondrial COI barcodes of nine cohabitated Taiwanese fireflies.PeerJ · 2022Article
- Molecular Evolution of Phototransduction Pathway Genes in Nocturnal and Diurnal Fireflies (Coleoptera: Lampyridae).Insects · 2021Article
- Genome-wide identification and gene-editing of pigment transporter genes in the swallowtail butterfly Papilio xuthus.BMC genomics · 2021Article
- Integrated Analysis of Transcriptome and Proteome to Reveal Pupal Color Switch inFrontiers in genetics · 2021Article
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Authors and funding
24 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fireflies are among the most charismatic insects for their spectacular bioluminescence, but the origin and evolution of bioluminescence remain elusive. Especially, the genic basis of luciferin (D-luciferin) biosynthesis and light patterns is largely unknown. Here, we present the high-quality reference genomes of two fireflies Lamprigera yunnana (1053 Mb) and Abscondita terminalis (501 Mb) with great differences in both morphology and luminous behavior. We sequenced the transcriptomes and proteomes of luminous organs of two species. We created the CRISPR/Cas9-induced mutants of Abdominal B gene without luminous organs in the larvae of A. terminalis and sequenced the transcriptomes of mutants and wild-types. Combining gene expression analyses with comparative genomics, we propose a more complete luciferin synthesis pathway, and confirm the convergent evolution of bioluminescence in insects. Using experiments, the function of the firefly acyl-CoA thioesterase (ACOT1) to convert L-luciferin to D-luciferin was validated for the first time. Comparisons of three-dimension reconstruction of luminous organs and their differentially expressed genes among two species suggest that two positive genes in the calcium signaling pathway and structural difference of luminous organs may play an important role in the evolution of flash pattern. Altogether, our results provide important resources for further exploring bioluminescence in insects.
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