ArticleScientific reports2020
Infralimbic cortex controls fear memory generalization and susceptibility to extinction during consolidation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Generalization of negative memories drives the development of psychological distress-related behaviors.Innovation (Cambridge (Mass.)) · 2026Article
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- Prefrontal hypoactivity correlates with immediate extinction deficit following Pavlovian fear conditioning with a chasing threat.Psychopharmacology · 2025Article
- HAT p300/CBP Activity in the Prelimbic Cortex Underlies Reconsolidation of Contextual Fear Memory.Molecular neurobiology · 2025Article
- The prelimbic prefrontal cortex mediates the development of lasting social avoidance as a consequence of social threat conditioning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Context controls the ability of unconditional stimulus deflation to mitigate fear relapse.Brain research · 2025Article
- Mild Traumatic Brain Injury Impairs Fear Extinction and Network Excitability in the Infralimbic Cortex.Journal of neurotrauma · 2025Article
- Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress on Memory and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- A covert cortical ensemble for learned fear suppression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- An infralimbic cortex neuronal ensemble encoded during learning attenuates fear generalization expression.bioRxiv : the preprint server for biology · 2024Article
- A hypothalamic circuit mechanism underlying the impact of stress on memory and sleep.bioRxiv : the preprint server for biology · 2024Article
- Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states.Neuron · 2024Article
- Infralimbic activity during REM sleep facilitates fear extinction memory.Current biology : CB · 2024Article
- Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.bioRxiv : the preprint server for biology · 2024Article
- Influence of Stress Severity on Contextual Fear Extinction and Avoidance in a Posttraumatic-like Mouse Model.Brain sciences · 2024Article
- Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits.Aging cell · 2024Article
- Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states.bioRxiv : the preprint server for biology · 2024Article
- Animal models of human insomnia.Journal of sleep research · 2023Review
- A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination.Nature communications · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lesioning or inactivating the infralimbic (IL) subregion of the medial prefrontal cortex before acquisition produces more generalized and extinction-resistant fear memories. However, whether and how it modulates memory specificity and extinction susceptibility while consolidation takes place is still unknown. The present study aims to investigate these questions using muscimol-induced temporary inactivation and anisomycin-induced protein synthesis inhibition in the rat IL following contextual fear conditioning. Results indicate that the IL activity immediately after acquisition, but not six hours later, controls memory generalization over a week, regardless of its strength. Such IL function depends on the context-shock pairing since muscimol induced no changes in animals exposed to immediate shocks or the conditioning context only. Animals in which the IL was inactivated during consolidation extinguished similarly to controls within the session but were unable to recall the extinction memory the following day. Noteworthy, these post-acquisition IL inactivation-induced effects were not associated with changes in anxiety, as assessed in the elevated plus-maze test. Anisomycin results indicate that the IL protein synthesis during consolidation contributes more to producing extinction-sensitive fear memories than memory specificity. Collectively, present results provide evidence for the IL's role in controlling generalization and susceptibility to extinction during fear memory consolidation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.