ArticleScientific reports2020
Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Diffuse white matter abnormality is independently predictive of neurodevelopmental outcomes in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Postnatal dexamethasone treatment for preterm infants at high risk for bronchopulmonary dysplasia is associated with improved regional brain volumes: a prospective cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- Brain MRI T2 hyperintensity and neurodevelopmental outcomes in neonatal encephalopathy.Pediatric research · 2025Article
- The Quartile Levels of Thyroid-stimulating Hormone at Newborn Screening Stratified Risks of Neurodevelopmental Impairment in Extremely Preterm Infants: A Population Cohort Study.Journal of epidemiology · 2024Article
- Structural connectivity at term equivalent age and language in preterm children at 2 years corrected.Brain communications · 2024Article
- A Semi-Supervised Graph Convolutional Network for Early Prediction of Motor Abnormalities in Very Preterm Infants.Diagnostics (Basel, Switzerland) · 2023Article
- Prenatal tobacco smoke exposure and risk of brain abnormalities on magnetic resonance imaging at term in infants born very preterm.American journal of obstetrics & gynecology MFM · 2023Article
- Diffuse excessive high signal intensity in the preterm brain on advanced MRI represents widespread neuropathology.NeuroImage · 2022Article
- MRI based radiomics enhances prediction of neurodevelopmental outcome in very preterm neonates.Scientific reports · 2022Article
- Magnetic resonance spectroscopy brain metabolites at term and 3-year neurodevelopmental outcomes in very preterm infants.Pediatric research · 2022Article
- Extracallosal Structural Connectivity Is Positively Associated With Language Performance in Well-Performing Children Born Extremely Preterm.Frontiers in pediatrics · 2022Article
- Early micro- and macrostructure of sensorimotor tracts and development of cerebral palsy in high risk infants.Human brain mapping · 2021Article
- Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period.Scientific reports · 2021Article
- Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm.The Journal of pediatrics · 2021Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Our objective was to evaluate the independent prognostic value of a novel MRI biomarker-objectively diagnosed diffuse white matter abnormality volume (DWMA; diffuse excessive high signal intensity)-for prediction of motor outcomes in very preterm infants. We prospectively enrolled a geographically-based cohort of very preterm infants without severe brain injury and born before 32 weeks gestational age. Structural brain MRI was obtained at term-equivalent age and DWMA volume was objectively quantified using a published validated algorithm. These results were compared with visually classified DWMA. We used multivariable linear regression to assess the value of DWMA volume, independent of known predictors, to predict motor development as assessed using the Bayley Scales of Infant & Toddler Development, Third Edition at 3 years of age. The mean (SD) gestational age of the cohort was 28.3 (2.4) weeks. In multivariable analyses, controlling for gestational age, sex, and abnormality on structural MRI, DWMA volume was an independent prognostic biomarker of Bayley Motor scores ([Formula: see text]= -12.59 [95% CI -18.70, -6.48] R
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