Evidence map›Paper›PMID 32985370›Full record

ArticleCirculation research2020

Arterial Stiffness Preceding Diabetes: A Longitudinal Study.

Mengyi Zheng, Xinyuan Zhang, Shuohua Chen, Yongjian Song, Quanhui Zhao, Xiang Gao, Shouling Wu

Abstract read
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In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 2 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 2 syntheses or guidelines pooled it, 256 citations in OpenAlex.

  1. Pooled it
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  3. Beneficial vascular effects of oral phosphatidylserine supplementation in type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mengyi Zheng *Graduate School (M.Z., Y.S.), North China University of Science and Technology, Kailuan General Hospital, Tangshan, Hebei Province, China.
Xinyuan Zhang *Department of Nutritional Sciences, the Pennsylvania State University, University Park, PA (X.Z., X.G.).
Shuohua ChenDepartment of Cardiology (M.Z., S.C., Y.S., Q.Z., S.W.), North China University of Science and Technology, Kailuan General Hospital, Tangshan, Hebei Province, China.
Yongjian SongGraduate School (M.Z., Y.S.), North China University of Science and Technology, Kailuan General Hospital, Tangshan, Hebei Province, China.
Quanhui ZhaoDepartment of Cardiology (M.Z., S.C., Y.S., Q.Z., S.W.), North China University of Science and Technology, Kailuan General Hospital, Tangshan, Hebei Province, China.
Xiang Gao *Department of Nutritional Sciences, the Pennsylvania State University, University Park, PA (X.Z., X.G.).
Shouling Wu *Department of Cardiology (M.Z., S.C., Y.S., Q.Z., S.W.), North China University of Science and Technology, Kailuan General Hospital, Tangshan, Hebei Province, China.
Kailuan General Hospital · CNPennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationalePrevious studies on the relationship between diabetes and arterial stiffness were mostly cross-sectional. A few longitudinal studies focused on one single direction. Whether the association between arterial stiffness and diabetes is bidirectional remains unclear to date.

objectiveTo explore the temporal relationship between arterial stiffness and fasting blood glucose (FBG) status. METHODS AND

resultsIncluded were 14 159 participants of the Kailuan study with assessment of brachial-ankle pulse wave velocity (baPWV) from 2010 to 2015, and free of diabetes, cardiovascular and cerebrovascular diseases, and chronic kidney disease at baseline. FBG and baPWV were repeatedly measured at baseline and follow-ups. Cox proportional hazard regression model was used to estimate hazard ratios and 95% confidence intervals (CIs) of incident diabetes across baseline baPWV groups: <1400 cm/s (ref), 1400≤ baPWV <1800 cm/s, and ≥1800 cm/s. Path analysis was used to analyze the possible temporal causal relationship between baPWV and FBG, among 8956 participants with repeated assessment of baPWV and FBG twice in 2010 to 2017. The mean baseline age of the observed population was 48.3±12.0 years. During mean 3.72 years of follow-up, 979 incident diabetes cases were identified. After adjusting for potential confounders, the hazard ratio (95% CI) for risk of diabetes was 1.59 (1.34-1.88) for the borderline arterial stiffness group and 2.11 (1.71-2.61) for the elevated arterial stiffness group, compared with the normal ideal arterial stiffness group. In the path analysis, baseline baPWV was associated with follow-up FBG (the standard regression coefficient was 0.09 [95% CI, 0.05-0.10]). In contrast, the standard regression coefficient of baseline FBG for follow-up baPWV (β=0.00 [95% CI, -0.02 to 0.02]) was not significant.

conclusionsArterial stiffness, as measured by baPWV, was associated with risk of developing diabetes. Arterial stiffness appeared to precede the increase in FBG.

Indexed as

Vascular StiffnessAdultAgedAnkle Brachial IndexBiomarkersBlood GlucoseCardiovascular DiseasesChinaDiabetes MellitusFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedPrognosisBiomarkersBlood Glucosearterial stiffnessbrachia-ankle pulse wave velocitydiabetes

Identifiers

PMID32985370
OpenAlexW3088444866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.