ArticleJournal of the American Heart Association2020
Association of Changes in Cardiovascular Health Metrics and Risk of Subsequent Cardiovascular Disease and Mortality.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Demographic and socioeconomic inequalities in ideal cardiovascular health: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Improving Cardiovascular Health in a Pediatric Preventive Cardiology Practice.The Journal of pediatrics · 2021Trial
- Epidemiology and cardiometabolic care in adults with ASCVD and high 10-year ASCVD risk: 2021 WHO STEPS study in Iran.Scientific reports · 2026Article
- Dietary Inflammatory Index, cardiovascular health, and long-term outcomes in hypertension: external validation in a Chinese percutaneous coronary intervention cohort.Frontiers in nutrition · 2026Article
- Racial and ethnic disparities in childhood cardiovascular health: evidence of the role of social disadvantage from NHANES 2013-2018.BMC medicine · 2025Article
- Comparing Life's Simple 7 and Life's Essential 8 With Risk of Heart Failure.JACC. Advances · 2025Article
- Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults.Aging and disease · 2025Article
- Life's Essential 8 cardiovascular health status of 18-69-year-old individuals in France.American journal of preventive cardiology · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Association between psoriasis and Life's Essential 8 among adults in the United States.Archives of dermatological research · 2025Article
- Changes in Cardiovascular Health, Genetic Risk, and Cardiometabolic Diseases: Evidence From a Large-Scale Cohort Study.Journal of the American Heart Association · 2025Article
- Sexual identity differences in ideal cardiovascular health among cisgender adults in the All of Us Research Program.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Promotion of Cardiovascular Health in Africa: The Alliance for Medical Research in Africa (AMedRA) Expert Panel.JACC. Advances · 2024Review
- Psychological and socio-economic correlates of cardiovascular health among young adults in Puerto Rico.American journal of preventive cardiology · 2024Article
- Enhancing the Cardiovascular Health Construct With a Psychological Health Metric for Predicting Mortality Risk.JACC. Advances · 2024Article
- Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study.Journal of geriatric cardiology : JGC · 2024Article
- Association of Ideal Cardiovascular Health in Youth with Cancer Risk in Adulthood: A Cardiovascular Risk in Young Finns Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Cumulative exposure to AHA Life's Essential 8 is associated with nonalcoholic fatty liver disease: a large cohort study.Nutrition & metabolism · 2024Article
- Association of change in cardiovascular health based on life's essential 8 with incident cardiovascular disease.American journal of preventive cardiology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
Background The extent to which change in cardiovascular health (CVH) in midlife reduces risk of subsequent cardiovascular disease and mortality is unclear. Methods and Results CVH was computed at 2 ARIC (Atherosclerosis Risk in Communities) study visits in 1987 to 1989 and 1993 to 1995, using 7 metrics (smoking, body mass index, total cholesterol, blood glucose, blood pressure, physical activity, and diet), each classified as poor, intermediate, and ideal. Overall CVH was classified as poor, intermediate, and ideal to correspond to 0 to 2, 3 to 4, and 5 to 7 metrics at ideal levels. There 10 038 participants, aged 44 to 66 years that were eligible. From the first to the second study visit, there was an improvement in overall CVH for 17% of participants and a decrease in CVH for 21% of participants. At both study visits, 28%, 27%, and 6% had poor, intermediate, and ideal overall CVH, respectively. Compared with those with poor CVH at both visits, the risk of cardiovascular disease (hazard ratio [HR], 0.26; 95% CI, 0.20-0.34) and mortality (HR, 0.35; 95% CI, 0.29-0.44) was lowest in those with ideal CVH at both measures. Improvement from poor to intermediate/ideal CVH was also associated with a lower risk of cardiovascular disease (HR, 0.67; 95% CI, 0.59-0.75) and mortality (HR, 0.80; 95% CI, 0.72-0.89). Conclusions Improvement in CVH or stable ideal CVH, compared with those with poor CVH over time, is associated with a lower risk of incident cardiovascular disease and all-cause mortality. The change in smoking status and cholesterol may have accounted for a large part of the observed association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.