ArticleAmerican journal of physiology. Renal physiology2020
Cerebral blood flow regulation in end-stage kidney disease.
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Central and peripheral arterial diseases in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2021Guideline
- Cardiorespiratory and oxygenation responses in iron-deficient anemic women during whole-body exercise under moderate hypoxia.European journal of applied physiology · 2026Trial
- The impact of intradialytic elastic band exercise on physical and cognitive abilities in patients on maintenance hemodialysis: a randomized controlled trial.Renal failure · 2025Trial
- The hemodynamic cost of intermittent hemodialysis and systemic organ stunning.Renal failure · 2026Review
- Cognitive function after kidney transplantation: longitudinal trajectories, associated factors, and clinical outcomes-a systematic review.International urology and nephrology · 2026Review
- Quantitative Electroencephalography in Hemodialysis: Scoping Review and Translational Framework.JMIR biomedical engineering · 2026Review
- Observational
- Intradialytic cerebral blood flow reduction occurs irrespective of vascular access type: a comparative study.BMC nephrology · 2026Article
- Blood pressure variability and cerebrovascular risk in maintenance hemodialysis versus peritoneal dialysis: a comparative study.Renal failure · 2025Article
- Cerebrovascular Reactivity and Cerebral Ischemia During Chronic Hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2025Article
- Acute Effect of Moderate-Intensity Interval Intradialytic Exercise on Cerebral Oxygenation in Hemodialysis Patients: A Randomized Crossover Trial.Journal of the American Society of Nephrology : JASN · 2025Article
- Article
- Treatment of chronic kidney disease in older populations.Nature reviews. Nephrology · 2024Review
- Blunted cerebral hemodynamic responses to incremental exercise in patients with end-stage renal disease.International urology and nephrology · 2024Article
- Longitudinal changes in diffusion tensor imaging in hemodialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2024Article
- Association between white matter hyperintensities and altered cerebral blood flow in maintenance hemodialysis patients: a longitudinal study.BMC nephrology · 2024Article
- Predictors and Outcomes of Acute Brain Injury in Patients on Venoarterial Extracorporeal Membrane Oxygenation after Cardiopulmonary Resuscitation.Acta Cardiologica Sinica · 2024Article
- Association between susceptibility value and cerebral blood flow in the bilateral putamen in patients undergoing hemodialysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis.Physiological reports · 2023Article
- Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease.Journal of personalized medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) experience an increased risk of cerebrovascular disease and cognitive dysfunction. Hemodialysis (HD), a major modality of renal replacement therapy in ESKD, can cause rapid changes in blood pressure, osmolality, and acid-base balance that collectively present a unique stress to the cerebral vasculature. This review presents an update regarding cerebral blood flow (CBF) regulation in CKD and ESKD and how the maintenance of cerebral oxygenation may be compromised during HD. Patients with ESKD exhibit decreased cerebral oxygen delivery due to anemia, despite cerebral hyperperfusion at rest. Cerebral oxygenation further declines during HD due to reductions in CBF, and this may induce cerebral ischemia or "stunning." Intradialytic reductions in CBF are driven by decreases in cerebral perfusion pressure that may be partially opposed by bicarbonate shifts during dialysis. Intradialytic reductions in CBF have been related to several variables that are routinely measured in clinical practice including ultrafiltration rate and blood pressure. However, the role of compensatory cerebrovascular regulatory mechanisms during HD remains relatively unexplored. In particular, cerebral autoregulation can oppose reductions in CBF driven by reductions in systemic blood pressure, while cerebrovascular reactivity to CO
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Registered trials
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