Evidence map›Paper›PMID 32985114›Full record

Trial reportObesity (Silver Spring, Md.)2020

Randomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge-Eating Disorder: 12-Month Follow-up.

Carlos M Grilo, Marney A White, Valentina Ivezaj, Ralitza Gueorguieva

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Associations Between the Use of Fitness and Diet Tracking Technology and Disordered Eating Behaviour: A Systematic Review.European eating disorders review : the journal of the Eating Disorders Association · 2025
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  17. Current and emerging directions in the treatment of eating disorders.Substance abuse : research and treatment · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlos M GriloDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-0245-3444
Marney A WhiteDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Valentina IvezajDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-8760-8040
Ralitza GueorguievaDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Treatment of Obesity and Binge Eating: Behavioral weight Loss versus Stepped CareR01DK049587 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2002 to 2020
$8.5M
Mid-Career Investigator Award in Eating and WeightK24DK070052 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2005 to 2015
$1.4M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K24 DK070052NIDDK NIH HHS R01 DK049587
6 · The paper itself

Abstract

objectiveThis study aimed to examine longer-term effects of behavioral weight loss (BWL) and Stepped Care for binge-eating disorder and obesity through 12-month follow-up after completing treatments.

methodsA total of 191 patients with binge-eating disorder/obesity were randomized to 6 months of BWL (n = 39) or Stepped Care (n = 152). Within Stepped Care, patients began BWL (1 month), treatment responders continued BWL, nonresponders switched to cognitive behavioral therapy, and all were randomized (double-blind) to weight-loss medication or placebo (5 months). Patients were independently assessed throughout/after treatment and at 6- and 12-month follow-ups.

resultsIntent-to-treat analyses of remission rates revealed that BWL and Stepped Care did not differ significantly at posttreatment (74.4% vs. 66.5%), 6-month follow-up (38.2% vs. 33.3%), or 12-month follow-up (44.7% vs. 41.0%). Mixed models of binge-eating frequency indicated significant reductions through posttreatment but no significant changes or differences between BWL and Stepped Care during follow-up. Mixed models revealed significant weight loss with no differences between BWL and Stepped Care (5.1% vs. 5.8%) at posttreatment and significant time effects (larger percent weight loss at 6-month than at 12-month follow-up) with no differences between BWL and Stepped Care (-5.1% vs. -5.2% and -3.4% vs. -5.0%, respectively).

conclusionsBinge-eating improvements and weight loss produced by BWL and adaptive Stepped Care did not differ significantly 12 months after completing treatments.

Indexed as

Binge-Eating DisorderCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedTime FactorsTreatment OutcomeWeight Loss

Identifiers

PMID32985114
PMCPMC7644623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.