ArticleJournal of molecular neuroscience : MN2021
Protective Effects of Propofol on Rats with Cerebral Ischemia-Reperfusion Injury Via the PI3K/Akt Pathway.
Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- MiR-122 activates PI3K/Akt signaling to suppress microglial activation and ferroptosis in ischemic brain injury.Metabolic brain disease · 2026Article
- Astragaloside IV suppresses neuroinflammation via PI3K/Akt/NF-κB to ameliorate cerebral ischemia-reperfusion injury based on network pharmacology analysis and experimental validation.Frontiers in immunology · 2026Article
- Propofol attenuates cerebral ischemia-reperfusion-mediated neuronal apoptosis and oxidative damage by regulating the miR-6838-5p/AQP11 axis.Archives of medical science : AMS · 2026Article
- Epidermal growth factor receptor modulation for neural repair: Implications for neurodegenerative disease therapy.Frontiers in molecular neuroscience · 2026Review
- Mechanisms of Action of Propofol in Modulating Microglial Activation in Ischemic Stroke.Molecules (Basel, Switzerland) · 2025Review
- Anesthetics in pathological cerebrovascular conditions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Review
- Targeting PI3K/Akt in Cerebral Ischemia Reperfusion Injury Alleviation: From Signaling Networks to Targeted Therapy.Molecular neurobiology · 2024Review
- Research progress of propofol in alleviating cerebral ischemia/reperfusion injury.Pharmacological reports : PR · 2024Review
- Mechanism of Resveratrol Improving Ischemia-Reperfusion Injury by Regulating Microglial Function Through microRNA-450b-5p/KEAP1/Nrf2 Pathway.Molecular biotechnology · 2023Article
- The Missing Piece? A Case for Microglia's Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics.Neurochemical research · 2023Review
- Crucial role of autophagy in propofol-treated neurological diseases: a comprehensive review.Frontiers in cellular neuroscience · 2023Review
- The effect of propofol on hypoxia- and TNF-α-mediated BDNF/TrkB pathway dysregulation in primary rat hippocampal neurons.CNS neuroscience & therapeutics · 2022Article
- Propofol postconditioning alleviates diabetic myocardial ischemia‑reperfusion injuryMolecular medicine reports · 2022Article
- Microglia autophagy in ischemic stroke: A double-edged sword.Frontiers in immunology · 2022Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we explored the effects of propofol on oxidative stress response, cytokine secretion, and autophagy in rats with ischemia-reperfusion (I/R) injury and oxygen-glucose deprivation (OGD)-stimulated primary microglia and analyzed the role of the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) pathway in this process. Rat models of I/R injury and OGD models of primary microglia were established. Neurobehavioral scores were evaluated 24 h after reperfusion, and oxidative stress indicators, cytokine levels, and autophagy-related markers of rats and OGD-activated primary microglia were evaluated. Activation of the PI3K/Akt pathway was also assessed. The results showed that propofol pretreatment can improve nerve function in rats with I/R injury, inhibit oxidative stress response and inflammatory cytokine secretion, and promote autophagy in rats with I/R injury and OGD-activated primary microglia, and that the PI3K-Akt pathway was activated in this process. Following the addition of a PI3K/Akt pathway inhibitor, the effects of propofol on autophagy in rats with I/R injury and primary microglia were inhibited significantly. The results indicate that propofol promotes autophagy via the PI3K/Akt pathway in cerebral I/R injury.
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