Evidence map›Paper›PMID 32984817›Full record

ArticleCerebral cortex communications2020

Abnormal Brain Development in Huntington' Disease Is Recapitulated in the zQ175 Knock-In Mouse Model.

Chuangchuang Zhang, Qian Wu, Hongshuai Liu, Liam Cheng, Zhipeng Hou, Susumu Mori, Jun Hua, Christopher A Ross, Jiangyang Zhang, Peggy C Nopoulos and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Cerebral cortex communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Animal models of Huntington's disease. Pros and cons.Brain, behavior, & immunity - health · 2025
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chuangchuang ZhangDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Qian WuDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Hongshuai LiuDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Liam ChengDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Zhipeng HouDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Susumu MoriDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jun HuaDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Christopher A RossDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jiangyang ZhangDeaprtment of Radiology, New York University Grossman School of Medicine, New York City, NY 10016, USA.
Peggy C NopoulosDepartments of Psychiatry, Neurology, Pediatrics, University of Iowa Carver College of Medicine, Iowa city, IA 52242, USA.
Wenzhen DuanDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-5933-6308
Johns Hopkins University · USKennedy Krieger Institute · USNew York University · USUniversity of Iowa · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Huntington's Disease biomarkers and therapeuticsR01NS082338 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN · 2013 to 2017
$2.0M
Imaging brain glucose uptake by onVDMP MRI in Huntington's DiseaseR21NS118079 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN, XU, JIADI · 2020 to 2020
$465k
Cerebrovascular Abnormalities in Huntington's DiseaseR21NS104480 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI DUAN, WENZHEN, HUA, JUN · 2018 to 2019
$446k
NIBIB NIH HHS P41 EB017183NINDS NIH HHS R01 NS082338NINDS NIH HHS R21 NS104480NINDS NIH HHS R21 NS118079
6 · The paper itself

Abstract

Emerging cellular and molecular studies are providing compelling evidence that altered brain development contributes to the pathogenesis of Huntington's disease (HD). There has been lacking longitudinal system-level data obtained from

Indexed as

abnormal brain developmentbrain atrophyHuntington’s diseasemouse modelMRI

Identifiers

PMID32984817
PMCPMC7501464
OpenAlexW3047219661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.