ArticleInternational journal of pharmaceutics: X2020
Noninvasive characterization (EPR, μCT, NMR) of 3D PLA electrospun fiber sponges for controlled drug delivery.
Article in International journal of pharmaceutics: X, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Electron paramagnetic resonance (EPR) meets drug delivery and biomaterials: a magnetic love story.Drug delivery and translational research · 2026Review
- Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters.International journal of pharmaceutics: X · 2024Review
- Electrospun Nanofibers: Shaping the Future of Controlled and Responsive Drug Delivery.Materials (Basel, Switzerland) · 2023Review
- Silicone matrices for controlled dexamethasone release: toward a better understanding of the underlying mass transport mechanisms.Regenerative biomaterials · 2023Article
- Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review.Polymers · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly porous 3D-scaffolds, made from cut, electrospun PLA fibers, are relatively new and promising systems for controlled drug-delivery applications. Because knowledge concerning fundamental processes of drug delivery from those scaffolds is limited, we noninvasively characterized drug-loading and drug-release mechanisms of these polymer-fiber sponges (PFS). We screened simplified PFS-implantation scenarios with EPR and μCT to quantify and 3D-visualize the absorption of model-biofluids and an oil, a possible drug-loading liquid. Saturation of PFS (6 × 8 mm, h x d) is governed by the high hydrophobicity of the material and air-entrapment. It required up to 45 weeks for phosphate-buffered saline and 11 weeks for a more physiological, surface-active protein-solution, indicating the slow fluid-uptake of PFS as an effective mechanism to substantially prolong the release of a drug incorporated within the scaffold. Medium-chain triglycerides, as a good wetting liquid, saturated PFS within seconds, suggesting PFS potential to serve as carrier-vessels for immobilizing hydrophobic drug-solutions to define a liquid's 3D-interface. Oil-retention under mechanical stress was therefore investigated.
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Registered trials
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