ArticleEClinicalMedicine2020
The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study.
Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- COVID-19-Induced Acute Pancreatitis: Clinical Profiles, Outcomes, and Prognostic Indicators From a Global Review-Based Synthesis.Health science reports · 2025Article
- Ammonia-to-Urea Ratio: A Noninvasive First-Line Tool for Detecting Clinically Significant Portal Hypertension.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Mid-regional pro-adrenomedullin: A rapid sepsis biomarker for diagnosing spontaneous bacterial peritonitis in cirrhosis.European journal of clinical investigation · 2025Article
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- Usefulness of procalcitonin at admission as a risk-stratifying biomarker for 50-day in-hospital mortality among patients with community-acquired bloodstream infection: an observational cohort study.Biomarker research · 2023Article
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- SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death.Medical sciences (Basel, Switzerland) · 2022Review
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- [Sodium-chlorine difference as a prognostic predictor in adult patients diagnosed with COVID-19].Revista medica del Instituto Mexicano del Seguro Social · 2022Article
- Thyroid-Stimulating Hormone Predicts Total Cholesterol and Low-Density Lipoprotein Cholesterol Reduction during the Acute Phase of COVID-19.Journal of clinical medicine · 2022Article
- Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach.Scientific reports · 2022Article
- Characteristics of 100 consecutive patients with COVID-19 referred to consultation-liaison psychiatry services in Qatar: A comparison of patients with delirium versus other psychiatric diagnoses.Qatar medical journal · 2022Article
- Clinical and epidemiological characteristics of COVID-19 mortality in Saudi Arabia.Saudi medical journal · 2021Article
- Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions.Translational psychiatry · 2021Review
- Promising Therapy for Heart Failure in Patients with Severe COVID-19: Calming the Cytokine Storm.Cardiovascular drugs and therapy · 2021Review
- Neuropsychiatric Complications of COVID-19.Current psychiatry reports · 2021Review
- Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients.Frontiers in immunology · 2021Article
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Authors and funding
24 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with severe COVID-19, no data are available on the longitudinal evolution of biochemical abnormalities and their ability to predict disease outcomes.
methodsUsing a retrospective, longitudinal cohort study design on consecutive patients with severe COVID-19, we used an extensive biochemical dataset of serial data and time-series design to estimate the occurrence of organ dysfunction and the severity of the inflammatory reaction and their association with acute respiratory failure (ARF) and death.
findingsOn the 162 studied patients, 1151 biochemical explorations were carried out for up to 59 biochemical markers, totaling 15,260 biochemical values. The spectrum of biochemical abnormalities and their kinetics were consistent with a multi-organ involvement, including lung, kidney, heart, liver, muscle, and pancreas, along with a severe inflammatory syndrome. The proportion of patients who developed an acute kidney injury (AKI) stage 3, increased significantly during follow-up (0·9%, day 0; 21·4%, day 14;
interpretationOur results point out the lack of the association between the inflammatory markers and the risk of death but rather highlight a significant association between renal dysfunction and the risk of COVID-19 related acute respiratory failure and death.
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Registered trials
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